Stabilty constant of binary complexes of Fe(III) and Mn(II) with medicinally important ligand chloramphenicol antibiotics in solution were determined by paper electrophoretic technique. Stability constant of the complexes were determined at 25°C temperature and 0.1M (HClO 4 ) ionic strength. Our study is based upon the migration of a spot of metal ions on a paper strip at different pH against mobility gives information about the binary complexes and permits to calculate their stability constant. The stability constant data revealed that chloramphenicol may be used as chelating agent in chelation for medical treatment of metal overload or poisoning.
Alizarin and its derivatives are well known colorimetric reagents for cations. The presence of two hydroxyl groups in positions 1 and 2 with respect to the quinoid oxygen makes it very suitable for the formation of chelates with metal ion. A number of studies have been carried out on the detection and determination of a number of transition metal 1,2,3 .
ABSTRACTQuantitative studies of complex formation from the determination of stability constants of the binary complexes of metal (II)/(III)-alizarin and also the mixed complexes of metal (II)/(III)-alizarin-NTA have been described using paper electrophoretic technique. The stability constant of metal-(II)/(III)-alizarin are found to be 10 5.14 , 104.84
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