Study of Stability Constants of Fe (Iii) And Mn (Ii) With Chloramphenicol by Paper Electrophoretic Technique

Abstract

Stabilty constant of binary complexes of Fe(III) and Mn(II) with medicinally important ligand chloramphenicol antibiotics in solution were determined by paper electrophoretic technique. Stability constant of the complexes were determined at 25°C temperature and 0.1M (HClO 4 ) ionic strength. Our study is based upon the migration of a spot of metal ions on a paper strip at different pH against mobility gives information about the binary complexes and permits to calculate their stability constant. The stability constant data revealed that chloramphenicol may be used as chelating agent in chelation for medical treatment of metal overload or poisoning.

Determination of Metal-Ligand Stability Constant of Transition Metal Complexes with Pharmacologically Active Ligand N-[(E)-(2- Nitrophenyl)methylen]isonicotinohydrazid

“…A pH meter was used to find the stability constant which is advantageous for the formation of a complex in solution. [21][22][23][24][25][26][27][28][29][30][31][32] Metal ions are known to affect the action of many drugs. 33 The stability constant of complexes has been found to be greater than zero, if all the possible stability constants for a given system have been determined that means it is possible to calculate the equilibrium activity of complexes.…”