Proton-ligand association constants of organic ligand N-[(E)-(2-Nitrophenyl) methylen]isonicotinohydrazid with Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) metal ions have been studied by pH-metric technique at 27±1ͦ C in 70%(v/v) ethanol-water medium at 1M (NaClO 4) ionic strength. Organic ligand was synthesized by condensation of equimolar mixture of Anti-mycobacterial agent with aromatic aldehyde. The reaction progress and purity of organic ligands were confirmed by thin layer chromatography. Formation of organic ligands was confirmed with the help of MP, IR, 1 H NMR, 13 C NMR and elemental analysis. The stability constants of these binary complexes were evaluated and order of stability constant found as Zn (II) >Ni (II) > Cu (II) > Mn (II) > Co (II).
Present research work describes the successful development of inner transition metal ion complexation, magnetic susceptibility study, thermodynamic parameters and biological applications of synthesized organic ligand. Stability constant Order of developed metal complexes of N-[-(4-chlorophenyl) methylene] isonicotinohydrazide was found as follows La(III) > Ce(III) > Sm(III). Positive μeff clearly indicates paramagnetic nature of developed complexes. During thermodynamic parameter examination we found stability constants for complexes decrease with an increasing temperature, indicating that the composition equilibrium is exothermic in nature. Also ΔH and ΔG were negative for all of the systems which suggested that all of the reactions were exothermic. The ΔS found positive for most of the complexes which indicate in metal-ligand binding process is entropy favourable. In antimicrobial evaluation, we observed that Sm+3 metal complexes of (N-[(E)-(4-chlorophenyl) methylene] isonicotinohydrazde) exhibit superior property specifically against gram negative bacteria with respect to organic ligand.
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