Citronella oil (Cymbopogon nardus) is an essential oil which useful as an antibacterial that is usually provided in the form of macroemulsion for topical use. absorption of macroemulsion through the skin relatively low, thermodynamically is not stable and can produce a separate phase in the storage period. The one of development emulsion system to get better characteristics is to form a microemulsion. Microemulsion is an oil and water dispersion stable thermodynamically stabilized by surfactants and in some cases a cosurfactant. The objective of this study was to formulatecitronella oil in the form of a stable microemulsion using nonionic surfactant. Optimization of the type and amount of emulsifier (surfactant) was required to formulate a stable microemulsion. In this study, microemulsion was evaluated during a month. Type and concentration of surfactant, cosurfactant, Citronella oil (Cymbopogon nardus) and water was optimized. A stable citronella oil microemulsion was successfully created with composition of 15% PEG 400 as cosurfactant, 15% tween 80 as surfactant, 2-4% Citronella oil as oil phase and 10% glycerin as humectant and distilled water as aqueous phase. From the observation, microemulsion formula has clear appearance but physically unstable during a month storage.
Background :For long time ago various research has been done on both curcuma and banana fruit. Result showed that curcumin which contained in curcuma and cytoindosin, tannin, amylum on banana function as antipeptic ulcer. PUD (peptic ulcer disease) is remain the most common disease of gastrointestinal tract, so which influence life quality, disorder in works, and higher of medical treatment cost. Most of patient of which expect prompt effect of preparations. Based on this, suspension was made to give the prompt effect, due to fine particles of the suspensoid which is not degradated or aggregated in time. The Aim :to obtain dry suspension from which is pharmaceutically stable from combination of curcuma (Curcuma longa L.) aethanolic extracts and the powder of banana (Musa balbisiana Colla.) flesh using a various of suspending agent. Method : it was experimental method which was a research method in laboratory conducted by preparing some formulation designs of dry suspension fromcombination of curcuma (Curcuma longa L.) aethanolic extracts and the powder of banana (Musa balbisiana Colla.) flesh. Conclusion :the suspending agent producing the pharmaceutically stable dry suspension is magnesium aluminium silicate with 4% concentration
A research of dissolution testing of patent and generic glibenclamide tablet have been done. The purpose of this research is to determine quality of patent and generic glibenclamide tablet that circulated in Makassar. Glibenclamide tablets patent and generic dissolution have been tested with paddle methode in 500 ml posfat buffer pH 7,4, medium was accomplished at 37 o C±0,5 the speed of 75 rpm. Aliquot retaken as much 5 ml is done at time intervas of 10, 20, 30, 45, and 60 mnutes and then, the concentrations is confiruxed by spektrofotometer UV-VIS at the 299 nm wavelength. Based on the dissolution experiment result, the acquired glibenclamide percentage that was dissolute from glibenclamide tablets generic A = 85,686 %, generic B = 81,336 % and paten = 126,665 % have fulfill the dissolution the condition according to British Pharmacphea 2008. That is the dissolute is not less than 75 % within 45 minutes. And the average of Dissolution value efficiency (ED) rate each glibenclamide tablet paten = 115,29 %, generic B = 72,409 % and generic A = 77,352 %.
Background :For long time ago various research has been done on both curcuma and banana fruit. Result showed that curcumin which contained in curcuma and cytoindosin, tannin, amylum on banana function as antipeptic ulcer. PUD (peptic ulcer disease) is remain the most common disease of gastrointestinal tract, so which influence life quality, disorder in works, and higher of medical treatment cost. Most of patient of which expect prompt effect of preparations. Based on this, suspension was made to give the prompt effect, due to fine particles of the suspensoid which is not degradated or aggregated in time. The Aim :to obtain dry suspension from which is pharmaceutically stable from combination of curcuma (Curcuma longa L.) aethanolic extracts and the powder of banana (Musa balbisiana Colla.) flesh using a various of suspending agent. Method : it was experimental method which was a research method in laboratory conducted by preparing some formulation designs of dry suspension fromcombination of curcuma (Curcuma longa L.) aethanolic extracts and the powder of banana (Musa balbisiana Colla.) flesh. Conclusion :the suspending agent producing the pharmaceutically stable dry suspension is magnesium aluminium silicate with 4% concentration
Red fruit oil is known to be very useful as antioxidants are beneficial for skin health, especially to prevent damage cell components that cause premature aging of the skin. Based on the study of antioxidant activity with IC 50 value of 53.47 µg / mL. This study aimed to obtain a formula that possess optimal physical stability. In this study, three formulas designed by varying the precursor, namely the formula I with soap formation ingredients palm oil and olive oil, the formula II with VCO soapforming ingredients and olive oil, and formula III with ingredients forming castor oil soaps and oils olives. Each physical stability of the formulations was evaluated by testing parameters include the foam test, hardness test, test the pH, organoleptic and sensory evaluation test on the skin. Results showed that the formula that has optimum physical stability is Formula I with component-forming material palm oil soaps and olive oil.
A research of dissolution testing of patent and generic glibenclamide tablet have been done. The purpose of this research is to determine quality of patent and generic glibenclamide tablet that circulated in Makassar. Glibenclamide tablets patent and generic dissolution have been tested with paddle methode in 500 ml posfat buffer pH 7,4, medium was accomplished at 37 o C±0,5 the speed of 75 rpm. Aliquot retaken as much 5 ml is done at time intervas of 10, 20, 30, 45, and 60 mnutes and then, the concentrations is confiruxed by spektrofotometer UV-VIS at the 299 nm wavelength. Based on the dissolution experiment result, the acquired glibenclamide percentage that was dissolute from glibenclamide tablets generic A = 85,686 %, generic B = 81,336 % and paten = 126,665 % have fulfill the dissolution the condition according to British Pharmacphea 2008. That is the dissolute is not less than 75 % within 45 minutes. And the average of Dissolution value efficiency (ED) rate each glibenclamide tablet paten = 115,29 %, generic B = 72,409 % and generic A = 77,352 %.
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