Background
To emphasize the importance of CT in the diagnosis of COVID-19 disease by comparing the thoracic CT findings of COVID-19 patients with positive RT-PCR results and patients with clinical suspicion of COVID-19 but with negative RT-PCR results.
Results
In our study, COVID-19 patients with positive RT-PCR results (RT-PCR (+) group) and patients with clinical suspicion of COVID-19 but negative RT-PCR results (RT-PCR (−) group) were compared in terms of CT findings. In CT images, ground-glass opacity and ground-glass opacity + patchy consolidation were the most common lesion patterns in both groups. No statistically significant differences in the rates and types of lesion patterns were observed between the two groups. In both groups, lesion distributions and distribution patterns were similarly frequent in the bilateral, peripheral, and lower lobe distributions. Among the 39 patients who underwent follow-up CT imaging in the first or second month, a regression in lesion number and density was detected in 18 patients from both groups. Consolidations were completely resorbed in 16 of these patients, and five patients had newly developed fibrotic changes. The follow-up CT examination of 16 patients was normal.
Conclusions
Due to the false-negative rate of RT-PCR tests caused by various reasons, clinically suspected COVID-19 patients with a contact history should be examined with CT scans, even if RT-PCR tests are negative. If the CT findings are positive, these patients should not be removed from isolation.
Objectives
The aim of this study was to evaluate the relationship between systemic oxidative balance, and the severity of the disease in patients with COVID 19.
Methods
Sixty-four patients were divided into three groups according to the severity of the disease: mild (n=28), moderate (n=11) and severe (n=25). Twenty-four healthy controls included to the study. Proinflammatory cytokines (IL-6 and TNF-α), D-dimer, fibrinogen, total oxidative status (TOS), total antioxidant status (TAS) were measured and oxidative stress index (OSI) was calculated.
Results
The mean age of severe group was significantly higher than the other groups (p=0.001). TAS levels were significantly decreased in all patient groups compared to controls, while serum TOS and OSI levels were significantly different in all three stages of the disease. Serum IL-6 and TNF- α levels were significantly elevated in severe group compared to other groups. TOS and OSI levels were also significantly correlated with IL-6, CRP, ferritin, fibrinogen, LDH and D-dimer.
Conclusions
TOS and OSI levels are an indicator of systemic oxidative balance in COVID-19 and related to the disease severity. They can be an important marker for evaluating the disease severity and used in the management of patients with COVID-19.
Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock.Oleuropein, one of the important components of olive leaf, has antioxidant and anti-in ammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 hours. The results showed that in the group treated with oleuropein; in ammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage uid (BALF), and lung tissue, and there were signi cant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination.Based on the ndings of the present study, oleuropein showed protective effects against LPS-induced ALI.
Asthma is an in ammatory disease that affects many people around the world, especially individuals of pediatric age. The effectiveness of tyrosol, a natural phenolic compound, was examined in the asthma model induced by ovalbumin (OVA).
MethodsFor this purpose, 4 groups, each consisting of 8 rats, were formed. Serum physiological was given to the control group for 21 days. OVA was given to OVA, OVA + Dexamethasone (Dexa) and OVA + tyrosol groups intraperitoneally and by inhalation. Additionally, 0.25 mg/kg Dexa was administered to the OVA + Dexa group and 20 mg/kg tyrosol to the OVA + Tyrosol group by oral gavage. Serum, blood, BALF uid and lung tissues of the rats were examined.
Resultsit was observed that the MDA level decreased, GSH level and GPx activity increased, and there was no change in CAT activity in the tyrosol treatment groups. It was also observed that NF-κB, TNF-α, IL-4, IL-5, IL-13, IFN-, and IgE levels decreased compared to the OVA group. However, no effect on IL-1 β level was observed. In addition, it was determined that tyrosol treatment increased the IL-10 level. The results of the histopathological investigation of lung tissue showed that tyrosol signi cantly ameliorated OVA-induced histopathological lesions. Additionally, PAS staining showed that mucus hypersecretion was signi cantly reduced with the use of tyrosol. In addition, it was determined that the number of eosinophils decreased signi cantly.
ConclusionsThe obtained results showed that tyrosol presented antioxidant and anti-in ammatory features on OVAinduced rats and preserved tissue architecture.
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