Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats

Abstract

Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock.Oleuropein, one of the important components of olive leaf, has antioxidant and anti-in ammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 hours. The results showed that in the group treated with oleuropein; in ammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage uid (BALF), and lung tissue, and there were signi cant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination.Based on the ndings of the present study, oleuropein showed protective effects against LPS-induced ALI.

Oleacein Attenuates Lipopolysaccharide-Induced Inflammation in THP-1-Derived Macrophages by the Inhibition of TLR4/MyD88/NF-κB Pathway

“…Several research groups reported the anti-oxidant and anti-inflammatory activities of oleocanthal and oleuropein [30][31][32][33][34][35][36][37], while those of OLC are still poorly defined. Recently, it has been shown that OLC exerts anti-inflammatory effects in human adipocytes challenged with TNF-α, a prototypic inflammatory stimulus, which could aid to explain the cardiometabolic benefit of EVOO consumption [32].…”

Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

“…After reviewing all of the publications, 10 studies were excluded because of missing outcome data ( Ehrhart et al, 2000 ; Tawadros et al, 2007 ; Nader and Baraka, 2012 ; An et al, 2014 ; Wang et al, 2015 ; Liu and Chen, 2016 ; Shen et al, 2017 ; Ni et al, 2019 ; Wang et al, 2019 ; Yang et al, 2019 ), and another 12 studies were excluded because multiple interventions were investigated ( Murakami et al, 2000 ; Lin et al, 2011 ; Li et al, 2014b ; Li et al, 2016a ; Li et al, 2016b ; Baradaran Rahimi et al, 2019 ; Ye et al, 2019 ; Duan et al, 2020 ; Yue et al, 2020 ; Choi et al, 2021 ; Zhang et al, 2021 ; Liu et al, 2022 ). In conclusion, 16 studies were included in this meta-analysis, as described below ( Shi et al, 2007 ; Yang et al, 2011 ; Chen et al, 2014 ; Yang et al, 2014 ; Yuan et al, 2014 ; Wei and Wang, 2017 ; Li et al, 2018a ; Li et al, 2018b ; Luo et al, 2019 ; Ren et al, 2019 ; Zhang et al, 2020 ; Ali et al, 2021 ; Dikmen et al, 2021 ; Li et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ) ( Figure 1 ).…”

“…Rats ranged in age from 6 to 8 weeks and in weight from 90 to 350 g. In terms of intervention, diterpenoid, monoterpenoid, sesquiterpenoid, and triterpenoid were used in seven studies ( Shi et al, 2007 ; Yang et al, 2011 ; Yang et al, 2014 ; Wei and Wang, 2017 ; Li et al, 2018a ; Li et al, 2018b ; Luo et al, 2019 ), three studies ( Yuan et al, 2014 ; Ren et al, 2019 ; Li et al, 2021 ), two studies ( Ali et al, 2021 ; Wang et al, 2021 ), and four studies ( Chen et al, 2014 ; Zhang et al, 2020 ; Dikmen et al, 2021 ; Wu et al, 2021 ), respectively. In addition, 13 studies used male rats ( Shi et al, 2007 ; Yang et al, 2011 ; Chen et al, 2014 ; Yang et al, 2014 ; Yuan et al, 2014 ; Wei and Wang, 2017 ; Li et al, 2018a ; Luo et al, 2019 ; Ren et al, 2019 ; Zhang et al, 2020 ; Dikmen et al, 2021 ; Li et al, 2021 ; Wang et al, 2021 ), whereas three studies did not report gender ( Li et al, 2018b ; Ali et al, 2021 ; Wu et al, 2021 ). Sprague Dawley rats were used in 11 studies ( Shi et al, 2007 ; Yang et al, 2014 ; Wei and Wang, 2017 ; Li et al, 2018a ; Li et al, 2018b ; Luo et al, 2019 ; Ren et al, 2019 ; Ali et al, 2021 ; Li et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ) and Wistar rats in five studies ( Yang et al, 2011 ; Chen et al, 2014 ; Yuan et al, 2014 ; Zhang et al, 2020 ; Dikmen et al, 2021 ).…”

“…In addition, 13 studies used male rats ( Shi et al, 2007 ; Yang et al, 2011 ; Chen et al, 2014 ; Yang et al, 2014 ; Yuan et al, 2014 ; Wei and Wang, 2017 ; Li et al, 2018a ; Luo et al, 2019 ; Ren et al, 2019 ; Zhang et al, 2020 ; Dikmen et al, 2021 ; Li et al, 2021 ; Wang et al, 2021 ), whereas three studies did not report gender ( Li et al, 2018b ; Ali et al, 2021 ; Wu et al, 2021 ). Sprague Dawley rats were used in 11 studies ( Shi et al, 2007 ; Yang et al, 2014 ; Wei and Wang, 2017 ; Li et al, 2018a ; Li et al, 2018b ; Luo et al, 2019 ; Ren et al, 2019 ; Ali et al, 2021 ; Li et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ) and Wistar rats in five studies ( Yang et al, 2011 ; Chen et al, 2014 ; Yuan et al, 2014 ; Zhang et al, 2020 ; Dikmen et al, 2021 ).…”

“…LPS was administered intravenously in seven studies ( Yang et al, 2011 ; Yang et al, 2014 ; Wei and Wang, 2017 ; Li et al, 2018a ; Li et al, 2018b ; Luo et al, 2019 ; Dikmen et al, 2021 ), intraperitoneally in one study ( Shi et al, 2007 ), and intratracheally in eight studies ( Chen et al, 2014 ; Yuan et al, 2014 ; Ren et al, 2019 ; Zhang et al, 2020 ; Ali et al, 2021 ; Li et al, 2021 ; Wang et al, 2021 ; Wu et al, 2021 ). The LPS dosage ranged from 0.1 to 10 mg/kg.…”