A series of new 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4-(arylmethyleneamino)-4H-1,2,4-triazole derivatives 3 were prepared in good yields by treatment of 4-amino-3-(4-chlorophenyl)-5-(pyridine- 4-yl)-4H-1,2,4-triazole (2) with selected aldehydes. Compounds 3 were reduced with NaBH4 to afford the corresponding 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4-(arylmethylamino)-4H-1,2,4-triazole derivatives 4. Eighteen new compounds were synthesized and characterized by elemental analyses, IR, 1H NMR and 13C NMR spectral data. The compounds were screened for their antioxidant and antiradical activities.
Highlights• As standard antioxidant, Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) was used.• The reducing power activities of the compounds were compared with BHT.• Values were the means of three replicates ± Standard deviation .
The acylhydrazone compound named ethyl N'-furan-2-carbonylbenzohydrazonate was synthesized by the condensation of ethyl benzimidate hydrochloride with furan-2-carbohydrazide. The treatment of the acylhydrazone with hydrazine hydrate afforded 4-amino-3-furan-2-yl-5-phenyl-1,2,4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. The obtained products were identified by FT-IR, (1)H-NMR, (13)C-NMR. A series of compounds were evaluated for their antibacterial, antiurease, and antioxidant activities. The results showed that the synthesized new compounds had effective antiurease and antioxidant activities.
A series of new bis triazole Schiff base derivatives (4) were prepared in good yields by treatment of 4-amino-3,5-diphenyl-4H-1,2,4-triazole (3) with bisaldehydes (1). Schiff bases (4) were reduced with NaBH 4 to afford the corresponding bisaminotriazoles (5). All the new compounds were characterized by IR, 1 H NMR and 13 C NMR spectral data. Their overall extraction (log K ex ) constants for 1 : 1 (M : L) complexes and CHCl 3 /H 2 O systems were determined at 25 6 0.1 C to investigate the relationship between structure and selectivity toward various metal cations. The extraction equilibrium constants were estimated using CHCl 3 /H 2 O membrane transfer with inductively coupled plasma-atomic emission spectroscopy spectroscopy. The stability sequence of the triazole derivatives in CHCl 3 for the metal cations was exhibited a characteristic preference order of extractabil-]. The compounds were tested for anti-microbial activity applying agar diffusion technique for 11 bacteria.
A new bis schiffbases, 3 a-b were synthesized compound 2 with various bis aldehydes. Compounds 3 a-b have been reduced with NaBH(4) to afford the corresponding bis amino triazole compounds 4 a-b. The obtained products 3 a-b and 4 a-b were identified by FTIR, (1)H-NMR, (13)C-NMR. A series of triazol derivatives were evaluated for their antibacterial, antioxidant, antiurease and antielastase activities. The results showed that the synthesized new bis-1,2,4-triazole derivatives had effective antioxidant, antiurease and antielastase activities.
A tetra-substituted phthalocyanine based on 4-[2-(4-nitrophenoxy)ethoxy]phthalonitrile carrying nitrophenyl group for the sensing of Zn 2? has been prepared and characterized by elemental analysis, FT-IR, 1 H and 13 C NMR, and MS spectral data. The sensing of Zn 2? is based on the fluorescence quenching of Pc. Both absorbance and fluorescence spectra of ZnPc exhibit distinct changes in visible region in response to treatment with Zn 2? ion in dimethyl sulfoxide. The fluorescence spectrum of the ligand showed quenching in the intensity of the signal at 688 nm for Zn 2? . The complex composition of ZnPc was found 1:1 by means of spectrophotometric and spectrofluorimetric titration data. The spectrofluorimetric method showed good sensitivity for Zn 2? with linear range and detection limit of 4.0 9 10 -6 -4.4 9 10 -5 and 2.49 10 -7 M, respectively.
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