Synthesis and Antioxidant Properties of Some New 3-(4-Chlorophenyl)-5- (pyridin-4-yl)-4H-1,2,4-triazole Derivatives

Bekircan, Olcay; Özen, Tevfik; Gümrükçüoğlu, Nurhan; Bektaş, Hakan

doi:10.1515/znb-2008-0512

Cited by 18 publications

(8 citation statements)

References 8 publications

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“…In addition, some 1,2,4-triazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles have also been reported as the compounds possessing antiurease activity (Amtul et al ., 2004; Aktay et al ., 2009; Bekircan et al ., 2008). Recently, some complexes of Schiff bases with metal ions showed significant inhibitory activities against urease (Shi et al, 2007; You et al, 2010) along with other metal complexes (Cheng et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus

et al. 2012

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2-[6-(Morpholin-4-yl)pyridin-3-ylamino]acetohydrazide (4) was obtained starting from 6-morpholin-4-ylpyridin-3-amine (2) via the formation of ester (3) and then converted to the corresponding Schiff bases (5, 6) with the reaction with aromatic aldehydes. The carbothioamide (9), obtained from the reaction of hydrazide with phenylisothiocyanate, was converted to the corresponding 1,2,4-triazole (11) and 1,3,4-thiadiazole (12) derivatives by the treatment with NaOH or H2SO4, respectively. The cyclocondenzation of 9 with 4-chlorophenacyl bromide or ethyl bromoacetate produced the corresponding 1,3-thiazole (10) or 1,3-thiazolidine derivatives (13), respectively. Antimicrobial and antiurease activities of newly synthesized compounds were investigated. Some of them were found to be active on M. smegmatis, and they displayed activity toward C. albicans and S. cerevisiae in high concentration. Compound 10 proved to be the most potent showing an enzyme inhibition activity with an IC50 = 2.37 ± 0.19 μM.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus

et al. 2012

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“…Aminotriazoles are structurally important precursors for obtaining various Schiff bases that have well‐known antimicrobial properties . Various triazole Schiff bases possessing varied significant biological activity have been reported to have antifungal, antibacterial, antitumor, plant growth‐regulating and cytotoxic activities. A wide range of transition metal complexes with biologically active compounds motivate studies for the preparation of new metal‐mediated antibiotics, antibacterial, antiviral, antiparasitic, radiosensitizing agents, and anticancer compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral characterization and biological studies of transition metal(II) complexes with triazole Schiff bases

Hanif

Chohan

2012

Applied Organom Chemis

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New metal based triazoles (1-12) have been synthesized by the interaction of novel Schiff base ligands (L 1 -L 3 ) with the Co(II), Ni(II), Cu(II) and Zn(II) metal ions. The Schiff base ligands and their all metal(II) complexes have been thoroughly characterized using various physical, analytical and spectroscopic techniques. In vitro bacterial and fungal inhibition studies were carried out to examine the antibacterial and antifungal profile of the Schiff bases in comparison to their metal(II) complexes against two Gram-positive, four Gram-negative and six fungal strains. The bioactivity data showed the metal(II) complexes to have more potent antibacterial and antifungal activity than their uncomplexed parent Schiff bases against one or more bacterial and fungal species. R Scheme 1. Preparation of the Schiff base ligands (L 1 -L 3 ). Scheme 2. Proposed structure of the metal(II) complexes (1-12).Synthesis, triazole Schiff bases, metal complexes, biological activity Average of ligands (L 1 -L 3 ) = 13.47 mm; average of complexes (1-12) = 17.24 mm.

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“…Their general structure includes a triazole ring fused to pyridine, pyridazine, pyrimidine, pyrazine, and triazine. Moreover, the structures incorporating triazoles fused to thiadiazine and thiadiazole display a broad spectrum of biological activities, even though few of them are available in the literature 11–16…”

Section: Introductionmentioning

confidence: 99%

Synthesis, extraction, and anti‐bacterial studies of some new bis‐1,2,4‐triazole derivatives part I

Gümrükçüoğlu

Uğraş

et al. 2011

J of Applied Polymer Sci

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A series of new bis triazole Schiff base derivatives (4) were prepared in good yields by treatment of 4-amino-3,5-diphenyl-4H-1,2,4-triazole (3) with bisaldehydes (1). Schiff bases (4) were reduced with NaBH 4 to afford the corresponding bisaminotriazoles (5). All the new compounds were characterized by IR, 1 H NMR and 13 C NMR spectral data. Their overall extraction (log K ex ) constants for 1 : 1 (M : L) complexes and CHCl 3 /H 2 O systems were determined at 25 6 0.1 C to investigate the relationship between structure and selectivity toward various metal cations. The extraction equilibrium constants were estimated using CHCl 3 /H 2 O membrane transfer with inductively coupled plasma-atomic emission spectroscopy spectroscopy. The stability sequence of the triazole derivatives in CHCl 3 for the metal cations was exhibited a characteristic preference order of extractabil-]. The compounds were tested for anti-microbial activity applying agar diffusion technique for 11 bacteria.

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Synthesis and Antioxidant Properties of Some New 3-(4-Chlorophenyl)-5- (pyridin-4-yl)-4H-1,2,4-triazole Derivatives

Cited by 18 publications

References 8 publications

Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus

Antimicrobial and antiurease activities of newly synthesized morpholine derivatives containing an azole nucleus

Synthesis, spectral characterization and biological studies of transition metal(II) complexes with triazole Schiff bases

Synthesis, extraction, and anti‐bacterial studies of some new bis‐1,2,4‐triazole derivatives part I

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