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Upconversion fluorescence emission of Er3+/Yb3+-doped Bi2O3–Na2O–Nb2O5–GeO2 heavy metal glass samples excited at 1.06 μm is experimentally investigated. The results reveal the existence of intense emission bands centered around 520, 545, and 655 nm. The germano-niobate based host glass presents high transparency in the region of 400–2700 nm, the capability of incorporating high dopant concentrations, high melting temperature, and large resistance to atmospheric moisture. The observed intensity of the green fluorescence emission, suggested that the niobium based host glass material plays an important role in the efficiency of the upconversion process. Emission lines centered at 425, 483, 503, 608, and 628 nm were also observed.

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BackgroundEvery year thousands of people are victims of burns, mainly scald burns. Many of these victims have small size wounds and superficial partial thickness and do not seek specialized medical care. As in Brazil Casearia sylvestris Sw., popularly known as guaçatonga is widely used for its analgesic, antiseptic and anti-inflammatory activities, this study sought to evaluate the effects of its hydroalcoholic extract in healing process of burns injuries.MethodsThe obtained extract was validated applying a thin layer chromatography and sophisticated validation method using Bothrops jararacussu snake venom that is necrotic and inflammatory, and by which guaçatonga extract was able to neutralize the irreversible neuromuscular blockade induced by the venom. After induction of the scald injury, the animals were treated daily with saline solution spray; spray containing extract; biofilm; or biofilm impregnated with extract.ResultsSignificant differences were observed between the four groups studied considering: extension of the healing area, neovascularization, fibroblast proliferation, and epithelialization.ConclusionThe anti-inflammatory and bactericidal effects of C. sylvestris Sw. suggests a potential therapeutic benefit in the treatment of inflammatory conditions in second-degree scald burn injuries, as well as, counteracting against the in vitro paralysis induced by B. jararacussu venom.

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The formation of mucosal ulcers is an end result of epithelial damage, and it occurs due to some specific causes, such as trauma, aphthous stomatitis, lichen planus and lichenoid reactions, cytotoxic effects of chemotherapy and radiation, and drug-induced hypersensitivity reactions and malignant settings. This study focused on films for target drug delivery with respect to the treatment of the diseases of the oral mucosa, specifically mucositis. The results of a single clinical study as a pre-experimental design was performed and followed up to the outcome until 30 days. The polymeric film was prepared in a mucoadhesive bilayer structure: the basal layer with lidocaine HCl had a faster release than the apical layer with benzydamine HCl and N-acetyl-cysteine. Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and SEM characterized the physical–chemical and morphological properties. The cell viability and cytotoxicity were evaluated in cell line MCF7. The transport mechanism of the solvent (swelling) and the drugs in the basal or apical layer (drug release) was explained with mathematical models. To evaluate the effect of movement inside the mouth, the folding endurance was determined. The mucoadhesive bilayer film is biologically safe and stimulates cellular proliferation. A single study in vivo demonstrated the therapeutic effect of the mucoadhesive bilayer film in buccal mucositis.

Neste trabalho pretende-se analisar elementos elásticos com respostas linear e não linear. Foi realizado o estudo comparativo entre três molas helicoidais, sendo uma linear e duas não lineares, e um tubo de látex. O estudo envolveu o levantamento das curvas de força versus distância e seus respectivos ajustes matemáticos para cada elemento elástico. A propostaé apresentar diferentes formas de abordar o tema elasticidade nas aulas de física, visando chamar a atenção do aluno de que a linearidade que trata a lei de Hooke aplica-se apenas para uma pequena faixa de valores de força e que em várias situações os elementos elásticos tem um comportamento não linear, sendo necessário lançar mão de outras relações matemáticas que se ajustem aos dados experimentais. Palavras-chave: lei de Hooke, mola, não linear.This paper aims to analyze elastic elements with linear and nonlinear responses. A comparative study was conducted of three helical springs, one linear and two nonlinear, and a latex tourniquet. The study involved a survey of force versus distance curves and their mathematical adjustments for each elastic element. The proposal is to present different ways of approaching the subject elasticity in physics classes, aiming to draw the attention of the student that the linearity is Hooke's law applies only to a small band of force values and that in many situations the elastic elements have a non-linear behavior, being necessary to use other mathematical relationships that fit the experimental data.