Recently, heterocyclic compounds and amino acids are of great interest to researchers owing to their various biological activities like; antimicrobial, anticancer, antiviral, anti-inflammatory, etc. Isatin is also a vital moiety containing N and O donor heteroatoms, and its Schiff base is used for complexation with metal ions which may alter their activities. The new metal complex of Ni has been synthesized using two ligands, 3-(2-phenylhydrazono) indolin-2-one (PHI) (L1) and amino acid Histidine (L2). The newly prepared ligand and the complex are further characterized by determination of molecular weight, element analysis, magnetic moment measurement, UV- visible, 1H NMR, and FTIR spectroscopy. The prepared compounds are examined for antimicrobial evaluation against several strains of bacteria and fungi.
The Sustainable/Greener approach is prioritized over the conventional approach because of its environment-friendly, less time-consuming, less energy-consuming, less hazardous compounds synthesis, and low expenditure. Using a greener approach involving the use of microwave, Cr complexes were synthesized from Schiff base and various bidentate ligands and compared with conventional methods. Condensing 2-amino pyridine and isatin produced Schiff base. Complexes of Cr(III) were synthesized by using some bio-potent secondary ligands with Schiff base. Both Schiff base and complexes were characterized by FTIR spectroscopy, 1H NMR spectroscopy, magnetic moment analysis, elemental investigation, etc. The synthesized compounds will be further used for biological evaluation that can be further used in drugs and agrochemical design.
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