Chronic Pain is a serious public health problem both in the United States and globally. Neurolysis therapy with radiofrequency, phenol/alcohol, and cryotherapy has been used in pain management for several decades. Characteristics of each modality are reviewed in this article including: history, mechanism, clinical indication, contraindication, side effects, and efficacy. An extensive literature search has been performed to determine which technique has the best efficacy while producing the least amount of adverse effects.

Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. Generally, very few complications are associated with Dermabond and are usually related to application techniques. Uncommonly, patients present with allergic reactions to the adhesive compounds; these allergies are often misdiagnosed as cellulitis or another infectious process, and are incorrectly treated. This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department.

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