Chronic Pain is a serious public health problem both in the United States and globally. Neurolysis therapy with radiofrequency, phenol/alcohol, and cryotherapy has been used in pain management for several decades. Characteristics of each modality are reviewed in this article including: history, mechanism, clinical indication, contraindication, side effects, and efficacy. An extensive literature search has been performed to determine which technique has the best efficacy while producing the least amount of adverse effects.
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