Diffuse Cutaneous Allergic Reaction to Dermabond

Abstract

Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. Generally, very few complications are associated with Dermabond and are usually related to application techniques. Uncommonly, patients present with allergic reactions to the adhesive compounds; these allergies are often misdiagnosed as cellulitis or another infectious process, and are incorrectly treated. This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department.

Contact Dermatitis Caused by Dermabond Advanced Use

“… 16 In addition, it carried a risk of sensitization to DBA for the wound with row surface exposure. 13 In our study, the length of the wound was long and the wound margin did not always oppose accurately in many patients; thus, the row surface tended to remain even though deep dermal suture was carried out before DBA use (Fig. 1 ).…”

Type IV Hypersensitivity Reaction to Dermabond (2-Octyl Cyanoacrylate) in Plastic Surgical Patients: A Retrospective Study

“…17 Michalowitz et al in 2020 compared Dermabond PRINEO with Exofin fusion and observed higher rates of Cellulitis in Dermabond cases. 18 We suppose that the body gets exposed to antigen (2-octyl cyanoacrylate) through small gaps in breast suture lines especially at the junctional points which are most liable sites for developing some wound gaps, 13 this in turn leads to sensitization of the body to Dermabond and subsequent development of type IV hypersensitivity reaction. In this study, we found out of the 4 cases who developed contact dermatitis, 3 developed it after their first contact with Dermabond, while as fourth case had past history of exposure to Dermabond in previous surgical procedure and in that patient we presume sensitization to Dermabond might had developed on its first application.…”

“…[5][6][7] There are few reports in the literature regarding development of allergic contact dermatitis post application of Dermabond. [8][9][10][11][12][13][14] However, there are very few studies regarding the incidence of contact dermatitis post application of Dermabond in surgical patients. In this retrospective study, we evaluated the incidence and characteristics of contact dermatitis post application of Dermabond (Trade name PRINEO manufactured by ETHICON) in patients who underwent plastic surgical breast procedures (Mastopexy and Reduction mammoplasty) in our hospital over the last 3 years.…”

Allergic reaction to Dermabond in gynaecologic surgery

“…Although there are only a few surgical cases reported regarding allergic reaction to topical application of 2-octyl cyanoacrylate, the current literature is rife with allergic reaction to other cyanoacrylate formulations especially when used during previous surgeries as outlined (Table 1) [13,[15][16][17][18][19][20][21][22][23][24].…”