Contact Dermatitis Caused by Dermabond Advanced Use

Abstract

Background:Dermabond Advanced (DBA) has been widely used globally; however, severe contact dermatitis (CD) can be a serious adverse effect of DBA use. In this study, we investigated the characterization and incidence rate of CD after using DBA and the safe use of DBA.Methods:One hundred consecutive patients who underwent skin closure with DBA were investigated. All patients were women undergoing breast reconstruction. DBA was applied to their trunk and limbs following reconstruction.Results:Seven patients (7%) presented with CD. Of these, 4 patients exhibited CD after the second DBA use; sensitization influence by the first DBA use was considered. One of 3 patients presenting with CD after the first DBA use was allergic to cosmetic glue, and the influence of immunological cross-reaction of acrylates was suggested.Conclusion:We consider that DBA use is inadequate for wounds with an improper margin and in dry and low-skin barrier areas such as the trunk and limbs because it may induce irritant CD and sensitization of DBA and subsequent allergic CD. Frequent use can also induce sensitization. If patients have a history of acrylate allergies, DBA use should be avoided because immunological cross-reaction from acetylates could result.

Postoperative contact dermatitis caused by skin adhesives used in orthopedic surgery

“…In this study of liquid adhesive-related contact dermatitis, 2.8% of patients developed contact dermatitis. Compared with the incidence (29/6008, 0.5%) reported by Chalmers et al, [ 11 ] the incidence in our study was higher, whereas it was lower than the incidence reported by Nakagawa et al [ 12 ] (7/100, 7%). Chalmers et al [ 11 ] used Dermabond Prineo skin closure system (Ethicon Inc., NJ) containing 2-octyl cyanoacrylate and Nakagawa et al [ 12 ] used Dermabond Advanced topical skin adhesive (Ethicon Inc., NJ) containing 2-octyl cyanoacrylate, each.…”

“…Skin adhesive-related contact dermatitis results from a type IV hypersensitivity reaction, which is a delayed reaction to a substance to which the patient was previously exposed. [ 12 ] It often presents with pruritis, eczema, oedema, and blisters, usually beginning 1 to 2 weeks after exposure. Allergic contact dermatitis is diagnosed by identifying a typical combination of skin lesion, previous exposure to the antigen, consistent patch and blood test results and tissue examination findings, and appropriate response to the dermatitis treatment.…”

Incidence and risk factor of allergic contact dermatitis to 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives

“…In addition, in joint arthroplasty surgery, Michalowitz et al 23 reported an incidence of 1.8% in 281 patients and Durando et al 24 reported 1.7% in 912 patients. Interestingly, Nakagawa et al 25 reported a 7.0% incidence of ACD in 100 patients who underwent breast reconstruction surgery. Except for Nakagawa et al, our incidence of 2.7% is somewhat higher than the previously reported incidence, but studies to date alone cannot clarify whether this is due to the difference in application site or patient demographics.…”

Adhesive Cements That Bond Soft Tissue Ex Vivo

“…); d) performance in wet environments, such as physiological fluids; and e) degradation without impeding healing or inflammation, while also maintaining adhesive strength long enough to facilitate native wound closure [23]. Many of the proposed adhesives utilize crosslinking initiators that may be toxic or unsuited for specific applications (i.e., photoinitiation [24], or aldehyde crosslinking, which may elicit an immune response [25]), and weaken rapidly in liquids [26]. For example, tissues repositioned with acrylate-based adhesives may heal better than with sutures [27], yet acrylate glues can elicit a fibrotic response, and weaken under wet-field conditions [21].…”