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Myositis is a rare but recognized complication of systemic lupus erythematosus (SLE). This study compares clinical and laboratory features in patients with SLE complicated by myositis with patients with SLE who do not have myositis. Thus we reviewed the notes of 10 patients with an overlap of biopsy-proven myositis and SLE and compared their clinical, serological and immunogenetic features with 290 patients with SLE without myositis. Our data suggests that patients with SLE associated with myositis are more likely to have alopecia, oral ulcers, erosive joint disease and pulmonary disease but less likely to have renal disease. Our SLE/myositis patients were likely to die at a younger age. The overall disease process seems to be influenced by the presence of anti-RNP autoantibodies.

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Objective. To test the hypotheses that 1) osteoarthritic (OA) knees at more advanced stages have less anteroposterior (AP) laxity compared with OA knees at milder stages, 2) AP laxity decreases over time, and 3) the absence of a decrease in AP laxity is associated with greater progression of medial tibiofemoral OA.Methods. The study group comprised 230 patients with knee OA (75% women, mean age 64 years, mean body mass index [BMI] 30 kg/m 2 ). At baseline and 18 months, AP laxity was measured (in millimeters of tibial translation, under AP shear loading), and semiflexed AP knee radiographs (with knee position confirmed by fluoroscopy) were obtained. Osteophytes were graded for each compartment, using a scale of 0-4. Disease progression was measured as the amount of medial joint space loss between baseline and followup, using linear regression with generalized estimating equations.Results. At baseline, measurements of AP laxity were lower in knees with a Kellgren/Lawrence (K/L) score of 4 (mean ؎ SD 5.0 ؎ 2.1 mm) than in those with a K/L score of 0-1 (mean ؎ SD 7.1 ؎ 2.6 mm). There was a weak negative correlation between osteophyte grade and AP laxity. In knees with a K/L score of 0-2, AP laxity was slightly lower at 18 months than at baseline. AP laxity at baseline was not a predictor of progression of OA. Knees without a decrease in AP laxity had a greater loss of medial joint space (0.22 mm greater, after adjusting for age, sex, and BMI) than did knees in which laxity decreased.Conclusion. AP laxity at baseline is not predictive of progression of OA. Although knees with a K/L score of 4 had less AP laxity than those with a K/L score of 0-1, most of this difference was attributable to the significant difference in AP laxity between knees with a K/L score of 0-1 and knees with a K/L score of 2 (i.e., definite osteophytes). Knees in which AP laxity decreased had less medial joint space loss than did knees without a decrease in AP laxity. The knee joint may successfully compensate for AP laxity; the absence of such compensation may have a deleterious effect.

The aim of this paper is to investigate whether comparable outcomes can be achieved when research evidence is translated into clinical practice in the management of osteoarthritis (OA) of the knee. An evidence-based physiotherapy programme for the management of OA of the knee was established at the Bristol Royal Infirmary (BRI). It incorporated both group education and exercise into a six week course. Outcomes from the programme were measured using the WOMAC self-evaluated questionnaire which is sub-divided into pain, stiffness and function sections with an additional visual analogue scale (VAS) for pain in each knee. Outcomes from the BRI programme were compared with those reported in four papers which used similar interventions and evaluation tools. A reduction in pain (VAS) of 43% was demonstrated following this programme compared with a mean reduction of 16% reported in the other programmes investigated. It is concluded that favourable outcomes for patients can be achieved by implementing evidence into practice, e.g. in the BRI knee programme.