SLE/myositis overlap: are the manifestations of SLE different in overlap disease?

Dayal, Nimesh; Isenberg, David

doi:10.1191/0961203302lu186oa

Cited by 51 publications

(66 citation statements)

References 20 publications

(19 reference statements)

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“…They found that those SLE/ myositis patients were likely to die at a younger age and that their overall disease evolution seems to be influenced by the presence of antiRNP autoantibodies. 23 Our lupus myositis patients are characterized by a frequent mild form of myositis with the presence on anti-RNP antibodies (66.6%), the frequency of hematological (100%), mucocutanous (66.6%) and central neurological involvement (seizure and cerebral vasculitis in 50%) for SLE with a good response to corticosteroid therapy in all cases. However, our study is small and potential confounding influences must be considered.…”

Section: Discussionmentioning

confidence: 98%

Systemic Lupus Erythematosusmyositis Overlap Syndrome: Report of 6 Cases

Maazoun

Frikha

Snoussi

et al. 2011

Clinics and Practice

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The incidence of myositis in patients with systemic lupus erythematosus (SLE) is low among different series. Here we attempt to describe the main features of SLE/myositis overlap syndrome. We retrospectively reviewed the medical records of 174 patients with SLE seen over 15-year period. All the patients fulfilled the revised American Rheumatology Association criteria for SLE. Patients who met The Bohan and Peter criteria for definite myositis were included in this study. Among those patients, six patients had an associated myositis (3.4% overall). They were 6 women with a mean age of 29 years (20–41 years). At the initial evaluation, 3 patients (50%) were complained from myalgia, and all patients had symmetrical muscle weakness (proximal muscle weakness in 6 cases with distal muscle weakness in 2 cases). The muscle disease was severe in 1 case. Involvements of muscles of the pharynx and upper esophagus were noted in 4 patients (66.6%). The creatine kinase (CK) levels were elevated in 4 cases with a mean rate of 2153.5 UI/L. The electromyogram (EMG) revealed signs of myositis in 5 cases. Muscle biopsy, performed in 5 patients, revealed an inflammatory myopathy changes in 4 cases. Antinuclear antibodies (ANA) were positive in all cases. All our patients were treated with high doses of corticosteroids with favorable outcome. Relapse of SLE disease had occurred in 2 patients. The association SLE-myositis is rare with heterogeneous presentation. Through our observations and literature data we will specify the characteristics of this association.

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Section: Discussionmentioning

confidence: 98%

Systemic Lupus Erythematosusmyositis Overlap Syndrome: Report of 6 Cases

Maazoun

Frikha

Snoussi

et al. 2011

Clinics and Practice

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“…Some oral lesions could easily be associated with the presence of a secondary sjogrens syndrome and the clinician must be careful to rule out sicca symptoms in evaluating any oral lesions. Besides the association of oral ulcers in patients with the overlap syndrome of myositis and SLE as noted by Dayal and Isenberg [16], no other firm connections between oral lesions and a specific disease process have been found.…”

Section: Oral Cavitymentioning

confidence: 90%

The Gastrointestinal Manifestations of Systemic Lupus Erythematosus: A Survey of the Literature

Schulz¹,

Derk²

2009

TOAUTOJ

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Systemic Lupus Erythematosus (SLE) is an autoimmune disease associated with auto-antibody production and resulting widespread inflammation that has potential to affect and damage many organ systems. Gastrointestinal manifestations of SLE are well documented in the literature but the exact extent and frequency of their presence is likely grossly underestimated. Patients present with vague complaints such as abdominal pain and nausea with non-specific physical exam findings and inconclusive diagnostic tests and serologic analysis. Recent research has helped to better clarify these manifestations of SLE and has demonstrated distinct involvement of almost every portion of the GI tract. This article is based upon an exhaustive review of the literature from 1976 to present date and summarizes the major advances in the identification and differentiation of gastrointestinal incarnations related to systemic lupus erythematosus. The review also encompasses theories of etiology of the various manifestations, summarizes accepted and experimental treatment regimens, and highlights the differential diagnosis of each presented topic, including disorders of the oropharynx, esophagus, stomach, small and large intestine, liver and gallbladder and beyond.

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“…If on one hand, it seems that cases with overlap are more likely to experience a benign course of disease [51]; on the other hand, some authors suggest this association as negative. For example, Dayal et al demonstrated how patients with myositis and SLE were more likely to die at a younger age and disease evolution in these subjects was influenced by the presence of anti-RNP autoantibodies [52]. In the same study, clinical and laboratory features of patients with myositis were compared to those without this manifestation.…”

Section: Systemic Lupus Erithematosusmentioning

confidence: 99%

“…In the same study, clinical and laboratory features of patients with myositis were compared to those without this manifestation. This study suggests that in overlap conditions, renal complications occur less frequently compared to the presence of alopecia, oral ulcers, erosive joint disease and pulmonary disease [52]. In a very recent study, 500 patients with SLE have been investigated for the presence of an ongoing inflammatory myopathy [53].…”

Section: Systemic Lupus Erithematosusmentioning

confidence: 99%