The SLICC Damage Index: past, present and future

Dayal, Nimesh; Gordon, Caroline; Tucker, Lori B.; Isenberg, David

doi:10.1191/0961203302lu190sa

Cited by 36 publications

(37 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the time of blood drawing, clinical status was assessed with the SELENA revision of the SLE disease activity index (SLEDAI) [15], and for the Systemic Lupus International Collaborating Clinics (SLICC)/ACR Damage Index [16]. Furthermore, patients were tested at the Hopkins clinical laboratory for lupus anticoagulant (by Russell Viper venom time, RVVT, with confirmatory tests), C3, and C4 levels (upper limits of normal: C3, 79 mg/dl; C4, 12 mg/dl), at time of visit.…”

Section: Methodsmentioning

confidence: 99%

IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE

Grönwall

Akhter

et al. 2012

Clinical Immunology

119

125

View full text Add to dashboard Cite

Emerging evidence suggests that there are IgM-autoantibodies that may play protective roles in SLE. While IgM are often considered polyreactive, we postulate that there are distinct sets of IgM-autoantibodies of defined autoreactive specificities relevant to different features of SLE. We examined the relationships between levels of IgM natural autoantibodies (NAbs) to apoptosis-associated phosphorylcholine (PC) or malondialdehyde (MDA) antigens, with lupus-associated autoantibodies and features of disease, in 120 SLE patients. IgM anti-PC was significantly higher in patients with low disease activity and less organ damage determined by the SELENA-SLEDAI, the physician's evaluation and the SLICC damage score. Furthermore, IgM anti-PC was significantly higher in patients without cardiovascular events. In contrast, IgM anti-cardiolipin and IgM anti-dsDNA were significantly higher in patients without renal disease. These results support the hypothesis that some IgM autoantibodies are part of a natural immune repertoire that provide homeostatic functions and protection from certain clinical lupus features.

show abstract

Section: Methodsmentioning

confidence: 99%

IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE

Grönwall

Akhter

et al. 2012

Clinical Immunology

119

125

View full text Add to dashboard Cite

show abstract

“…The Damage Index records irreversible changes in organ function that have been present for at least 6 months 17 . The presence of diabetes mellitus was recorded as part of this index.…”

Section: Methodsmentioning

confidence: 99%

Brain Magnetic Resonance Imaging in Newly Diagnosed Systemic Lupus Erythematosus

et al. 2008

View full text Add to dashboard Cite

Objective We wished to determine the prevalence of cerebral atrophy and focal lesions in a cohort of patients with newly diagnosed systemic lupus erythematosus (SLE) and the association of these brain abnormalities with clinical characteristics. Methods A total of 97 patients with SLE, within 9 months of diagnosis, with 4 or more American College of Rheumatology classification criteria, were enrolled. Brain magnetic resonance imaging was performed. Results The patients were 97% female, mean age 38.1 (SD 12.2) years, education 15.1 (2.8) years; 59 Caucasian, 11 African American, 19 Hispanic, 5 Asian, and 3 other ethnicity. Cerebral atrophy was prevalent in 18% (95% CI 11%–27%): mild in 12%, moderate in 5%. Focal lesions were prevalent in 8% (95% CI 4%–16%): mild in 2%, moderate in 5%, severe in 1%. Patients with cerebral atrophy were more likely to have anxiety disorder (p = 0.04). Patients with focal lesions were more likely to be African American (p = 0.045) and had higher Safety of Estrogens in Lupus Erythematosus National Assessment SLEDAI scores (p = 0.02) and anti-dsDNA (p = 0.05). Conclusion In this population with newly diagnosed SLE, brain abnormalities were prevalent in 25% of patients. These findings suggest that the brain may be affected extremely early in the course of SLE, even before the clinical diagnosis of SLE is made. Followup of these patients is planned, to determine the reversibility or progression of these abnormalities and their association with and potential predictive value for subsequent neuropsychiatric SLE manifestations.

show abstract

“…However, as discussed elsewhere, the SDI does not capture certain issues that are unique to children (e.g., retarded growth). In addition, the assessment of damage in childhood may also be made more difficult by the ability of children to recover and regenerate to a greater degree than adults, as is the case with (early) avascular necrosis or osteoporosis, both of which can be reversible once better control of the disease and restoration of the normal growth process are accomplished [70]. In view of these facIn view of these facIn view of these factors, a modified version of the SDI that includes additional criteria such as growth failure and delayed puberty has been proposed but requires further validation and improvement [71,72].…”

Section: Uncommon Presentationsmentioning

confidence: 99%

Childhood- and adult-onset lupus: an update of similarities and differences

Papadimitraki

Isenberg²

2009

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune rheumatic disease. Although its highest prevalence is among women of childbearing age, the disease is not confined within this population. A total of 15-20% of cases of SLE are diagnosed in children younger than 16 years (childhood-onset lupus). Although there have been few studies directly comparing childhood- to adult-onset lupus, there is substantial evidence to suggest that pediatric lupus patients display some differences in their disease profile compared with adult-onset populations. Overall, an increased male-to-female ratio, a higher prevalence of nephritis and CNS involvement necessitating a more sustained need for steroids and immnosuppressive drugs, and a higher prevalence of progression to end-stage renal disease are distinguishing features of childhood-onset lupus. In contrast, a higher prevalence of pulmonary involvement, arthritis and discoid lupus are reported in adult-onset SLE patients. Furthermore, childhood-onset lupus patients may experience a serious negative impact on their psychosocial and physical development, issues that pose extra challenges to healthcare providers. Growth delay, osteoporosis, the psychological effect of steroid-induced alterations of the physical image, and often poor treatment compliance are the issues that need to be addressed in pediatric lupus populations. In this review, we compare the epidemiological, clinical and laboratory features, and treatment options of childhood- and adult-onset lupus, and comment on the applicability of the instruments that measure activity, severity and cumulative disease damage in childhood-onset disease. In addition, we highlight special issues of concern for pediatric lupus patients, discussing the significance in the transition from pediatric to adult rheumatology care.

show abstract

The SLICC Damage Index: past, present and future

Cited by 36 publications

References 13 publications

IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE

IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE

Brain Magnetic Resonance Imaging in Newly Diagnosed Systemic Lupus Erythematosus

Childhood- and adult-onset lupus: an update of similarities and differences

Contact Info

Product

Resources

About