High dose (5–7.5×1015 cm−2) arsenic implantation was conducted in the energy range 50–120 keV into three types of (100)Si substrates: (i) bare Si, (ii) with a thermally grown screen oxide (775 Å), and (iii) preamorphized surface layer produced by self-implantation. The substrates were subsequently furnace annealed at 600 °C in N2. Cross-section transmission electron microscopy (XTEM) revealed that in all cases discrete layers of As related clusters and small dislocation loops occurred at depths matching the projected ranges of As into the Si substrates and original amorphous/crystalline interfaces respectively. The atomic profiles of As obtained by secondary ion mass spectrometry (SIMS) from these samples did not show any redistribution of As. The carrier concentration profiles from the spreading resistance measurements indicate that only 30% of As was electrically active. Comparison of XTEM and SIMS suggests that nucleation of the clusters occurred in the regions where As was present above the solid solubility limit in Si. The presence of recoiled oxygen has been found to stabilize the clusters.
Introduction: Nuclear protein in testis midline carcinoma (NMC) is a rare and extremely aggressive carcinoma (median survival < 7 months) with no effective treatment options. CUDC-907 is a novel small molecule inhibitor of histone deacetylase (HDAC) and phosphoinositide 3-kinase (PI3K) enzymes currently being investigated in multiple tumor types, including NMC. Case Report: A 61-year old female NMC patient enrolled on study CUDC-907-102 (NCT02307240) after rapidly progressing through two prior treatments. The patient's assessable sites of disease consisted of right pleural effusion, right hilar soft tissue, and segment IV liver. Treatment was well tolerated with toxicities primarily consisting of manageable diarrhea and thrombocytopenia. The patient remains on active treatment after more than 32 months of stable disease. Discussion: Dysregulation of MYC in NMC is believed to play a central role in pathogenesis. CUDC-907 has demonstrated potent suppression of MYC expression and anti-tumor activity in preclinical NMC models, providing a mechanistic rationale for the prolonged disease stabilization observed here. The treatment of additional NMC patients with CUDC-907 is needed to further evaluate this promising report. Conclusion: This case demonstrates a rare success in the treatment of a devastating disease using only a novel small molecule, warranting further investigation of CUDC-907 in NMC.
A two dimensional model of nucleation and growth is described which is consistent with the following experimental phenomena observed in the regrowth of ion-implanted silicon: (1) Substrate orientation effect on regrowth kinetics. (2) Impurity effects on regrowth kinetics. (3) The activation energy dependence of regrowth rate. (4) Impurity redistribution and supersaturation effect.
The connection between diet and psoriasis has been of increasing interest to patients and physicians. An IRB approved 30-question survey assessing the popularity of specific diet regimens and nutritional supplements was offered voluntarily to psoriasis patients at the
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.