Benzimidazole derivatives are versatile nitrogen containing heterocyclic compounds which have long been known as a promising class of biologically active compounds possessing wide variety of biological and pharmacological activities like antibacterial, anti-inflammatory, anti-ulcer, anti-diabetic etc. Scientists have elucidated that Benzimidazole system possesses the variable sites like position 2 and 5 which can be suitably modified to yield potent therapeutic agents.The present review covers the chemistry and pharmacological activities of substituted bezimidazoles.
Oxadiazole or furadiazole is a five membered heterocyclic nucleus and is considered to be derived from furan by replacement of two methane (-CH=) group by pyridine type nitrogen. Oxadiazole is a versatile lead compound for designing potent bioactive agents. The derivative of oxadiazole nuclei (1,3,4-oxadiazole) showed diverse biological activities such as anti-microbial, anti-inflammatory, anti-tubercular, anti-convulsant, anti-cancer, anti-HIV, hypoglycemic and genotoxic. In this article, we have tried to compile some of the major researches carried out for the compound 1,3,4oxadiazole.
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