Benzimidazole: An Overview

Abstract

Benzimidazole derivatives are versatile nitrogen containing heterocyclic compounds which have long been known as a promising class of biologically active compounds possessing wide variety of biological and pharmacological activities like antibacterial, anti-inflammatory, anti-ulcer, anti-diabetic etc. Scientists have elucidated that Benzimidazole system possesses the variable sites like position 2 and 5 which can be suitably modified to yield potent therapeutic agents.The present review covers the chemistry and pharmacological activities of substituted bezimidazoles.

A Comprehensive Review on Therapeutic Potential of Benzimidazole: A Miracle Scaffold

“…All synthesized compounds showed significant anthelmintic activity. Amongst all prepared 2-substituted benzimidazole molecules, compound (11b) revealed greatest anthelmintic activity (Palit et al, 2016). The paralysis and death time were recorded and compared with standard drug piperazine citrate which is strong.…”

“…Benzimidazole is an aromatic bicyclic heterocyclic ring system. It contains benzene and imidazole ring fused together at 4 and 5 position (Palit et al, 2016). They show both acidic and basic properties due to amphoteric nature of nitrogen atoms (Tahlan et al, 2019).…”

Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives

“…The benzimidazole derivatives drew attention to interesting pharmacophores in drug discovery. Benzimidazole derivatives have been utilized in medicinal chemistry for the development of antihistaminics [ 22 ], antiulceratives [ 23 ], anthelmintics [ 24 ], and antipsychotics [ 25 ]. Furthermore, several benzimidazoles have been reported as antiviral [ 26 ], anticoagulant [ 27 ], anti-inflammatory [ 28 ], antibacterial [ 29 ], and anticancer [ 30 ].…”

Synthesis of Benzimidazole derivatives containing Schiff base exhibiting antiurease activities

“…Benzimidazoles are significant heterocyclic compounds because of their structurally similarity to purine and its derivatives, proteins inside the bacterial cell wall and it is the basic part of the structure of vitamin B 12. [7] Also, benzimidazoles have a wide range of biological activities including antioxidant [8], anticancer, antimicrobial [9], antihistaminic, antiinflammatory [10], enzyme inhibitions [11,12] and they have an important role in the field of medicine. A condensation reaction between aldehydes or ketones with primary amines in alcoholic conditions form Schiff bases.…”