Review on Substituted 1,3,4-Oxadiazole and Its Biological Activities

Palit, Rituparna; Saraswat, Nikita; Sahoo, Jagannath

doi:10.7897/2230-8407.07212

Cited by 14 publications

(7 citation statements)

References 11 publications

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“…There are a countless number of reports suggesting the broad ranges of biological properties of oxadiazole derivatives are available. [52][53][54][55] So, a molecular fusion of quinoline with oxadiazole following the pharmacophoric approach is a better technique to achieve new therapeutics.…”

Section: Quinoline-oxadiazole Hybridsmentioning

confidence: 99%

Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

Panda

Chakroborty

2020

ChemistrySelect

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The emergence of drug resistance and low specificity with side effects are the significant challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this is an imperative prerequisite to develop novel anticancer agents through mainstream medicinal chemistry approaches. The intriguing quinoline and its derivatives have demonstrated as significant building blocks for the locating of new promising anticancer agents. Consequently, quinoline moiety with the addition of suitable congeners would offer a strategy for the development of potential drug candidates. This present review article summarizes the recent advances (2018‐2020) of quinoline hybrids and their anticancer activity. The mechanism action and plausible structure‐activity relationship have discussed.

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Section: Quinoline-oxadiazole Hybridsmentioning

confidence: 99%

Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

Panda

Chakroborty

2020

ChemistrySelect

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“…The 1,3,4‐oxadiazole (Figure ) is a heterocycle with well‐known antibacterial and antifungal properties, and it is widely used as a scaffold in agricultural and medicinal chemistry (Palit, Saraswat, & Sahoo, ; Xu et al, ; Zhang et al, ). The combination of two fungicidal moieties, SLB and the 1,3,4‐oxadiazole, led to a series of novel stilbene derivatives active in vivo against three phytopathogenic fungi, P. cubensis , C. lagenarium , and Septoria cucurbitacearum (from Cucurbita moschata Duch).…”

Section: Heterocycle‐based Stilbene Derivativesmentioning

confidence: 99%

Stilbene derivatives as new perspective in antifungal medicinal chemistry

Filippis

Ammazzalorso

Amoroso

et al. 2019

Drug Development Research

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The high incidence and mortality of invasive fungal infections and serious drug resistance have become a global public health issue. There is an urgent need for alternative antimicrobials to control fungal infections and targeting it by antifungal substances from the natural sources represents a promising new strategy for the development of novel antifungal agents. Resveratrol (3,5,4′‐trihydroxy‐trans‐stilbene) is a phytoalexin produced by plant species in response to environmental stress or pathogenic attacks. It has many known and potential therapeutic applications in human general homeostasis; it mediates a great number of biological responses relevant for human health such as anticancer, cardio and neuroprotective, antioxidant, and antimicrobial activities. Resveratrol is a natural antifungal agent, therefore it can be considered as a scaffold for designing structural relatives potentially capable of mediating more intense responses in a more specific way. Also, stilbenes produced by several plants may be useful lead structure for the chemical synthesis of antifungal. Their antifungal potential represents a useful solution to the drug resistance and side effect complications that occur after pharmacological treatment of infectious diseases. The purpose of this review is to present an overview on resveratrol derivatives, both natural and synthetic, with antifungal activity and summarize the chemical structure and the therapeutic versatility of stilbene‐containing compounds.

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“…Oxadiazole derivatives represent a class of heterocyclic compounds belonging to the azole family, which have an abundance of π-electrons and unshared electron pairs on the nitrogen and oxygen atoms which can interact with d-orbitals of metals to produce protective films on the surface [23]. Many oxadiazole derivatives have low toxicity [24] and a broad spectrum of biological activities [25][26][27], including antioxidant and antimicrobial activities.…”

Section: Introductionmentioning

confidence: 99%

Experimental characterization, machine learning analysis and computational modelling of the high effective inhibition of copper corrosion by 5‐(4‐pyridyl)‐1,3,4‐oxadiazole‐2‐thiol in saline environment

Varvara

Berghian‐Grosan

Bostan

et al. 2021

Electrochimica Acta

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An oxadiazole derivative with functional groups favouring its adsorption on copper surface, namely 5-(4-Pyridyl)-1,3,4-oxadiazole-2-thiol, has been explored as potential inhibitor of copper corrosion in 3.5 wt.% NaCl. Electrochemical evaluation by electrochemical impedance spectroscopy, potentiodynamic polarization and SVET reveals inhibition efficiencies exceeding 99%. Surface microscopy inspection and spectroscopic analysis by Raman, SEM-EDX and XPS highlight the formation of a compact barrier film responsible for long-lasting protection, that is mainly composed of the organic molecules. Machine Learning algorithms used in combination with Raman spectroscopy data were used successfully for the first time in corrosion studies to allow discrimination between corroded and inhibitor-protected metal surfaces. Quantum Chemistry calculations in aqueous solution and Molecular Dynamic studies predict a strong interaction between copper and the thiolate group and an extensive coverage of the metal surface, responsible for the excellent protection against corrosion.

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Review on Substituted 1,3,4-Oxadiazole and Its Biological Activities

Cited by 14 publications

References 11 publications

Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

Stilbene derivatives as new perspective in antifungal medicinal chemistry

Experimental characterization, machine learning analysis and computational modelling of the high effective inhibition of copper corrosion by 5‐(4‐pyridyl)‐1,3,4‐oxadiazole‐2‐thiol in saline environment

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