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Protease inhibitors (PIs) are potent antiretroviral agents, although their rapid intestinal and hepatic metabolism, mainly by the cytochrome P450 pathway, leads to a low systemic exposure. Boosting PIs has had a significant impact on the treatment of type-1 human immunodeficiency virus (HIV-1) infection by improving their pharmacokinetic profile, resulting in more durable efficacy, higher barrier to resistance, reduced pill burden and dosing frequency [1]. Conclusion:Trough 48 weeks, switching DRV/RTV to DRV/COBI is safe and maintains viral efficacy, without significant changes in lipid profile or renal function.

Introduction: Sudden cardiovascular death (SCD) constitutes the main challenge for Cardiology in this century. One out of every two cardiovascular deaths is due to this universal health problem. Objective: To present scientific evidence that justifies this global challenge, and to mention the research results of the Research Group on Sudden Death (GIMUS) of Cuba. Material and method: Research results of the SUCADES study carried out in Cuba are presented, applying the research protocol contained in the Cuban Guide for SCD research works. Results: The GIMUS has developed in a period of 27 years' scientific research with the application of a diagnostic algorithm and the use of a Primary Data Collection Model to 33,718 natural deaths, documenting 2,252 sudden deaths, representing 6.7% of global mortality recorded. Conclusions: The global challenge that SCD represents is justified by its high incidence, its impact on the economic, health and social systems of the countries and the drama in its presentation. It is necessary to achieve a comprehensive vision in the confrontation with this universal health problem, assuming the main actions from interdisciplinarity to achieve results that allow its reduction.