INTISARIDaun ekor naga (Rhapidhophora pinnata, Schott ) merupakan tanaman yang sering digunakan sebagai obat tradisional untuk penyakit hipertensi, stroke dan kanker. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak daun ekor naga(Rhapidhophora pinnata, Schott) terhadap struktur histologi hati mencit (Mus musculusL). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan menggunakan 28 ekor mencit betina yang dibagi menjadi 4 kelompok perlakuan. Kelompok P0 (kontrol) diberikan NaCL dan kelompok P1, P2 dan P3 diberikan ekstrak daun ekor naga dengan dosis berturut-turut 50, 100 dan 150 mg/KgBB selama 14 hari secara oral (gavage). Mencit dibedah pada hari ke-15 untuk diambil hatinya kemudian diamati kerusakan berupa degenerasi lemak, degenerasi hidropis dan nekrosis. Data dianalisis dengan uji Kruskal-Wallis. Hasil analisis menunjukkan tidak terdapat perbedaan nyata antara kelompok kontrol dengan perlakuan terhadap parameter degenerasi lemak, hidropis dan nekrosis, namun ditemukan adanya hemoragi, kongesti dan infiltrasi sel radang.Kata kunci :Rhapidhophora pinnata Schott,hati, mencit ABSTRACT Rhapidhophora pinnata, Schott is a traditional medical plant that has been use remedy for treatment of hypertension, stroke. Aims of this research is to determine the effect of Rhapidhophora pinnata Schott leaf extract toward mouse (Mus musculus L) liverhistological structure. This research used completely randomized design with 28 female mice that were divide into 4 groups of P0 (control) received 0,9% NaCl, group P1, P2, and P3 received 50, 100 and 150 mg/kg bw respectively by oral administration. The treatment were given daily for 14 days. All of the mice were sacrificed by ether after 15 days. The liver were examined for their histopathological changes, namely fatty degeneration, hydropic degenaration and necrosis. Results were statistically analised by Kruskal-Wallis method. Treatment groups showed no significant differences with regard of liver histopatological changes, however hemorrhage, sinusoid congestion and inflamatory cell infiltration were found in liver.
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