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The effectiveness of low-level laser therapy (LLLT) in the presence of an infectious process has not been well elucidated. The aim of the study was to evaluate the effects of LLLT in an experimental model of septic arthritis. Methods. Twenty-one Wistar rats were divided as follows: control group, no bacteria; placebo group, bacteria were inoculated; Treated group, bacteria were injected and treatment with LLLTwas performed. To assess nociception, a von Frey digital analgesimeter was applied. Synovial fluid was streaked to analyze bacterial growth. The standard strain of S. aureus was inoculated in the right knee. LLLT was performed with 660 nm, 2 J/cm2, over 10 days. After treatment, the knees were fixed and processed for morphological analysis by light microscopy. Results. It was found that nociception increases in the right knee. There was a lack of results for the seeding of the synovial fluid. The morphological analysis showed slight recovery areas in the articular cartilage and synovia; however, there was the maintenance of the inflammatory infiltrate. Conclusion. The parameters used were not effective in the nociception reduction, even with the slight tissue recovery due to the maintenance of inflammatory infiltrate, but produced no change in the natural history of resolution of the infectious process.

Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. //dx.doi.org/10.17058/reci.v1i1.9350 Páginas 01 de 03 não para fins de citação Objetivos: O gene New Delhi metalo ß-lactamase (blaNDM) pode ser encontrado no plasmídeo de variadas cepas de enterobactérias conferindo multirresistência a diferentes classes de antimicrobianos, bem como a fácil disseminação do gene entre essas cepas. O presente estudo teve por objetivo relatar o isolamento da primeira cepa de Klebsiella pneumoniae produtora de carbapenemase codificada pelo gene blaNDM, de um paciente internado em uma Unidade de Terapia Intensiva (UTI) no oeste do Paraná. Descrição do caso: Um paciente masculino, 73 anos, deu entrada no hospital referindo dores abdominais sendo iniciada antibioticoterapia com ciprofloxacina e metronidazol. Passou por diversos procedimentos cirúrgicos e evoluiu para sepse com desenvolvimento de K. pneumoniae resistente aos carbapenêmicos produzindo carbapenemase codificada pelo gene blaNDM que teve como foco infeccioso uma ferida operatória abdominal, porém o paciente foi a óbito. Conclusão: Infere-se que, a confirmação da cepa resistente que produz a carbapenemase do tipo NDM e a conduta médica em localizar o foco da sepse, bem como a não resposta aos antimicrobianos utilizados e as diversas complicações cirúrgicas contribuíram para que o paciente evoluísse a óbito. Fazem-se necessários, portanto, estudos complexos sobre cepas que produzem esse tipo de carbapenemase, para uma escolha adequada da combinação de antimicrobianos que serão eficazes no tratamento, bem como ações junto a Comissão de Controle de Infecção Hospitalar (CCIH) que visem conter as diferentes infecções, principalmente a realização da coleta de cultura de vigilância desses pacientes em ambiente hospitalar, a fim de evitar a seleção de cepas cada vez mais resistentes a esses. Descritores: Antimicrobianos. Enterobactérias. Carbapenêmicos. Infecções Bacterianas. Infecção Hospitalar.Objectives: The New Delhi metalo β-lactamase gene (blaNDM) can be found in the plasmid of various enterobacteria strains, conferring multidrug resistance to different antimicrobials classes, as well as the easy spread of the gene between these strains. The present study aimed to report the isolation of the first strain of Klebsiella pneumoniae, carbapenemase producer, encoded by the blaNDM gene, of a patient admitted to an Intensive Therapy Unit (ITU) in the west of Paraná. Case description: A male patient, 73 years old, was admitted to the hospital referring abdominal pains, being initiated antibiotic therapy with ciprofloxacin and metronidazole. He underwent several surgical procedures where he evolved to sepsis with development of K. pneumoniae resistant to carbapenems producing carbapenemase encoded by the gene blaNDM that had as an infectious focus an abdominal surgical wound, but he eventually evolved to death. Conclusion: It is inferred that, the confirmation of the resistant strain tha...

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