COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. The cost of his treatment requires a large amount of money. This study aims to analyze the cost-effectiveness of drug use in hospitalized patients with COVID-19 in the category of non-comorbid suspects with combination antiviral and antibiotic therapy at the Bandung Hospital Period July – December 2021. This study uses a non-analytic descriptive method. Data collection was carried out retrospectively by accessing medical record data. Samples that met the inclusion criteria in this study were 48 patients. Cost-effectiveness analysis was carried out by calculating the Average Cost Effectiveness Ratio (ACER) and Incremental Cost Effectiveness Ratio (ICER), then a sensitivity analysis was carried out to determine the parameters that affect cost-effectiveness by increasing drug costs to 2.5%, 5%, 7.5%. . The results of the analysis show the use of combinations of antivirals and antibiotics in COVID-19 patients, namely there are 16 variables and the most cost-effective (cost-effective) treatment is the combination of ceftriaxone inj with oseltamivir obtained at ACER = Rp. 1.005.724, the combination of azithromycin with ceftriaxone inj. is obtained at ICER = Rp.-2.113,412. The results of the sensitivity analysis showed that there was no change in ACER and ICER even though the drug price was increased up to 7.5% and the combination of inj ceftriaxone with oseltamivir remained the most cost-effective.
Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonas aeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline as the standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.
Piperin dari tanaman famili Piperaceae termasuk golongan senyawa nitrogen yang memiliki beberapa aktivitas farmakologi. Piperin memiliki kelarutan yang rendah di dalam air sehingga mengakibatkan bioavailabilitasnya buruk. Beberapa pendekatan telah digunakan untuk memaksimalkan bioavailabilitas obat, salah satunya adalah pembentukan kompleks terinklusi atau metode kompleksasi. Zat pengompleks yang paling banyak digunakan adalah siklodekstrin, yang memiliki 6, 7 atau 8 molekul dekstrosa (α, , -siklodekstrin) terikat pada konfigurasi 1,4 membentuk cincin dengan diameter tertentu yang berlainan. Artikel ini membahas tentang biopiperin terinklusi dengan siklodekstrin serta aktivitas antiinflamasi piperin.
Phyllanthus emblica is empirically used to treat various diseases. Chemical compounds in this plant includes benzene derivatives, diterpen and monoterpen, furanolacton, flavonoids and sterols. The purpose of this research is to investigate anti-hyperglycemic activity of P. emblica. The diabetic animal model was obtained by administration of alloxan 120 mg/kg BW intraperitonial. The rats were divided into 9 groups, i.e., normal group, negative control (1% CMC), positive control (glibenclamide 0.5 mg/kg BW) and P. emblica leaves and bark ethanol extract at the dose of 500, 750, and 1000 mg/kg BW. Determination of flavonoid content was performed through colorimetric method using UV-Vis spectrophotometer at 425 nm. After 7 days of induction, the entire group was treated for 21 days, fasting blood glucose was performed on days 0, 1, 8, 15 and 22. Then the data of fasting blood glucose level in mice was treated with one way ANOVA analysis and advanced test with post hoc Least Significant Differences (LSD) method. The percentage of the blood glucose decrease from the animal treated with leaves extract at doses of 500, 750 and 1000 mg/kg BW, respectively, were 22.47%; 21.03%; and 24.52%, while those of bark extract were 32.19%; 31.61%; and 37.24%, respectively. Determination of total flavonoid level showed that the highest amount of flavonoids was observed in leaves (35.838 mg/g Quercetin). In conclusion, P. emblica bark and leaves showed anti-hyperglycemic activity. Keywords: anti-hyperglycemic, alloxan, Phyllanthus emblica, Wistar
<p><em>Mangosteen (Garcinia mangostana L.) is known as a plant rich in antioxidants and has various pharmacological activities. This study aims to determine the activity of the ethanolic extract of G. mangostana L. to decrease mercury levels in the kidneys. Mangosteen rind was extracted using 96% ethanol using the maceration method to form a thick extract. The experimental animals used in this study were Swiss Webster strain mice which were grouped into normal group (CMC suspension 0.5%), negative control (induction of HgCl2 solution), positive control (induction of HgCl2 solution followed by administration of curcumin at a dose of 100mg/KgBW). , and the test group was given mangosteen peel extract at a dose of 200mg/kgBW, 400mg/kgBW, 600mg/kgBW. In the test group, mice were induced using HgCl2 for 14 days, followed by administration of ethanol extract of mangosteen rind for 24 days. Observations were made with kidney organ surgery and observations were made using Atomic Absorption Spectrophotometry (AAS) and analyzed using ANOVA. The test results showed mercury accumulation in the negative, positive control group, and the test doses of 200, 400 and 600mg/kgBW, respectively, were 44.3mg/kg, 7.3mg/kg, 36.46mg/kg, 35.7mg/kg. kg and 31.34mg/kgBW with an effective dose of 600mg/KgBW.</em></p>
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.