Analisis Efektivitas Biaya Penggunaan Obat Pada Pasien Rawat Inap Penyakit Covid-19 Kategori Suspek Non-Comorbid Dengan Terapi Obat Kombinasi Antivirus Dan Antibiotik Di Salah Satu Rumah Sakit Kota Bandung Periode Juli – Desember 2021

Abstract

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. The cost of his treatment requires a large amount of money. This study aims to analyze the cost-effectiveness of drug use in hospitalized patients with COVID-19 in the category of non-comorbid suspects with combination antiviral and antibiotic therapy at the Bandung Hospital Period July – December 2021. This study uses a non-analytic descriptive method. Data collection was carried out retrospectively by accessing medical record data. Samples that met the inclusion criteria in this study were 48 patients. Cost-effectiveness analysis was carried out by calculating the Average Cost Effectiveness Ratio (ACER) and Incremental Cost Effectiveness Ratio (ICER), then a sensitivity analysis was carried out to determine the parameters that affect cost-effectiveness by increasing drug costs to 2.5%, 5%, 7.5%. . The results of the analysis show the use of combinations of antivirals and antibiotics in COVID-19 patients, namely there are 16 variables and the most cost-effective (cost-effective) treatment is the combination of ceftriaxone inj with oseltamivir obtained at ACER = Rp. 1.005.724, the combination of azithromycin with ceftriaxone inj. is obtained at ICER = Rp.-2.113,412. The results of the sensitivity analysis showed that there was no change in ACER and ICER even though the drug price was increased up to 7.5% and the combination of inj ceftriaxone with oseltamivir remained the most cost-effective.

Cost-Effectiveness Analysis of Favipiravir and Remdesivir as COVID-19 Treatment in South Tangerang, Banten Province - Indonesia

“…The findings of this study are further corroborated by Fathurrahman et al in 2023, which posits a higher prevalence of female patients relative to male patients. 8 In addition, the COVID-19 pandemic has had a significant impact on the physical and psychological well-being of working moms, leading to increased workload and stress levels. These factors can have detrimental effects on the body's immune system, as highlighted by Safarina et al in 2021.This finding aligns with the research conducted by Khaerunnisa et al, in 2022, which suggests that women have a higher susceptibility to stress when confronted with novel situations.…”

“…These factors can have detrimental effects on the body's immune system, as highlighted by Safarina et al in 2021.This finding aligns with the research conducted by Khaerunnisa et al, in 2022, which suggests that women have a higher susceptibility to stress when confronted with novel situations. [8][9][10] Pharmaceuticals Remdesivir and Favipiravir are antiviral agents that have demonstrated efficacy in individuals with moderate to severe symptoms. These medications belong to the class of prodrug nucleotide analogues and are capable of inhibiting the RNA polymerase of the COVID-19 virus.…”