A twenty-one year old female with previously unsuspected neurofibromatosis presented for evaluation of a blind painful eye. Histopathologic examination of the enucleated specimen revealed choroidal thickening with ovoid bodies and proliferation of connective tissue with pigment-containing cells and ganglion-like cells. Electron microscopic study of the latter cell population revealed typical morphologic features of ganglion cells, including numerous electron-dense intracellular granules and an abundance of mitochondria and rough endoplasmic reticulum. These pathologic findings were interpreted as consistent with the diagnosis of choroidal ganglioneuroma occurring in the context of ocular neurofibromatosis. The literature concerning this unusual tumor is reviewed and the possible relationship of this lesion to neurofibromatosis and other disorders of neural cresent proliferation are briefly discussed.
Economists, political scientists, and journalists around the world have suggested that the COVID-19 pandemic will have long-term effects on twenty-first-century global society. As a precipitating factor in the final collapse of the post-1945 world order, the pandemic has been seen as an epochal turning point in human history. This article will examine the long-term effects that the pandemic may have on the protection and promotion of cultural heritage, which has become a major economic and political undertaking in the post-World War II era, with earlier roots in elite aesthetics and the rise of mass tourism in the nineteenth century. This article will identify some dramatic changes in economic activity and politics that may transform the social role of cultural heritage in the coming decades.
This article deals with the momentous events that took place in Judah in the short period of time between 732 (and mainly 722) and 701 BCE. A torrent of refugees from the North, mostly from the areas bordering on Judah, dramatically changed the demographic structure in the Southern Kingdom. The population seems to have at least doubled and included significant north Israelite communities. This situation created, in fact, a pan-Israelite state. Hezekiah reacted to this challenge in two ways, both aimed at strengthening the authority of the central government. Countryside shrines were abolished and the cult was centralized in the Jerusalem Temple, probably in an attempt to prevent the new immigrants from visiting the Bethel temple in their old homeland. In the same short period of time, the story of the early days of the Davidide dynasty was first put in writing, combining southern and northern traditions in a single national narrative.
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