IPV was documented in approximately 12% of participants. Population-based surveys need to be done to investigate further.

Background: The aim of the study was to assess the role of colour Doppler velocimetry of the uterine arteries as a predictor of intrauterine contraceptive devices (IUCD)-induced abnormal uterine bleeding.Methods: A prospective study was performed on 120 women (60 without AUB and 60 with AUB) who had copper IUCD inserted as a method of contraception. Detailed history, general and local examination and relevant investigations were done. Pulsatility index (PI) and resistance index (RI) of uterine artery measured at 3 months after IUCD insertion.Results: Cut-off levels for PI and RI of uterine arteries were set. PI cut-off level <2.09 with sensitivity of 58.3%, specificity of 61.67% and area under the curve (AUC) of 0.666. RI cut-off level ≤0.83 with sensitivity of 53.33%, specificity of 66.67% and AUC of 0.703. These cut-off levels were associated with abnormal uterine bleeding.Conclusions: Initial measurement of uterine artery Doppler indices (PI and RI) before IUCD insertion could be useful in predicting IUCD-induced abnormal uterine bleeding which is the major cause of method withdrawal during the first year of use and accordingly women could be counseled to consider another method of contraception.

No abstract

Fanconi anemia (FA) is an autosomal recessive disorder, both genetically and phenotypically. It is characterized by chromosomal instability, progressive bone marrow failure, susceptibility to cancer, and various other congenital abnormalities. It involves all the three cell lines of blood. So far, biallelic mutations in 21 genes and one x-linked gene have been detected and found to be associated with FA phenotype. Signs and symptoms start setting in by the age of 4 to 7 years, mainly hematological symptoms. This includes pancytopenia, that is, a reduction in the number of white blood cells (WBCs), red blood cells (RBCs), and platelets. Therefore, the main criteria for diagnosis of FA include skeletal malformations, pancytopenia, hyperpigmentation, short stature, urogenital abnormalities, central nervous system, auditory, renal, ocular, and familial occurrence. Patients showing signs and symptoms of FA should be thoroughly evaluated. A complete blood count will reveal a reduced number of RBC, WBC, and platelets, that is, pancytopenia. Chromosomal breakage study/stress cytogenetics should be done in patients with severe pancytopenia. Momentousness timely diagnosis of current disease, prenatal diagnosis, and genetic counseling should be emphasized.