Background: Little is known about a possible association between sleep duration and the incidence of atrial fibrillation (AF), in healthy people. In this systematic review, we conducted a literature search to examine possible association between sleep duration and the incidence of AF.Methods: Scientific databases (PubMed, Web of Knowledge and Embase) were searched using relevant Medical Subject Headings and keywords, to retrieve studies written in English and published until November 2017. Only population-based observational studies were included. Since sleep duration categories were not consistent, it was feasible to run a meta-analysis.Results: The average follow-up of the patient population was 1,633.1±1,232.9 (median: 1,438.0) days. Patients who underwent 2-4 and ≥5 DCCVs had mSix eligible studies were included. Long sleep duration (≥ 8 hours) was found to be associated with an increased risk of AF (adjusted hazard ratio (aHR) = 1.13; 95% CI: 1.00-1.27 and aHR= 1.5, 95% CI: 1.07-2.10) in two studies. One study reported that sleep duration less than 6 hours was associated with an increased risk of AF (aHR= 1.58, 95% CI: 1.18 -2.13) compared to sleeping for 6-7 hours. In two studies, mean sleep duration was lower in AF groups compared to the non-AF group. Insomnia was associated with an increased risk of AF in another study (aHR= 1.33, 95% CI: 1.25-1.41).Conclusions: Unhealthy sleep duration, defined as either less than 6 hours or more than 8 hours, may be associated with an increased risk of AF.
"Hippo signaling has been recognized as a newly identified tumor suppressor signaling pathway that can regulate cellular processes including regeneration, cell death, differentiation, and development. Its dysregulation through overexpression of YAP (Yes-associated protein) and TAZ (PDZ-binding motif) as two main oncogenic factors of the Hippo pathway has a crucial role in several cancers. Because of the limited prognosis and therapeutic targets, further understanding of molecular pathways involved in tumorigenesis is one of the interesting issues in studies. Here, we demonstrated that some viruses, through dysregulation of the Hippo signaling pathway can be implicated in transformation, metastasis, and chemotherapeutic drug resistance in virus-related cancer and also help processes involved in the pathogenesis of viral infection such as persistence "
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