Background
Blood group antigens are one of the most important antigens in humans that have an impact on susceptibility to disease and may be used as a prognosis factor in different diseases such as covid-19.
Objectives
Study aimed to investigate the relationship between ABO blood groups and Rhesus antigen and susceptibility to COVID-19.
Methods
The clinical data of 398 subjects were used in the investigation collected from 148 cases vs. 250 controls. This information was obtained from Shahid Sadoughi Hospital of Yazd (IRAN) University. blood groups and outcomes was assessed using statistical tests for four populations: COV + vs. COV− and COV +/deceased vs. COV +/live.
Results
Out of a total of 148 COVID19 patients, 80 (54/1%) were male, 68 (45/9%) were female. Among these patients 33 (22/6%) had type A+, 44 (30/1%) had type B+, 13 (8/9%) had type AB+ and 36 (24/7%) had type O+. On the other hand, out of a 148 patients, 126 (86/3%) had positive blood types and 20 (13/7%) had negative blood types. As a result, no significant difference was found in the relationship between ABO blood groups and RH type and susceptibility to COVID-19 (p-value= 0.392 and p-value=0.847, respectively). Other data showed a significant difference between patients group with other parameters such as age (p-value<0.001) and gender (p-value<0.001).
Conclusion
Although in this study there was no association between blood type and RH type with COVID-19, findings about association between age and gender can confirm the results of previous studies.
Viral infections have been considered as possible destructive factors that influence male fertility. The aim of this study was to determine the prevalence of human herpes viruses 1-5 (HHV1-5), adeno associated virus (AAV) and human papilloma virus (HPV) in semen and whether these influence semen quality. DNA extraction was performed using phenol-chloroform protocol, then three different nested-PCRs were done to detect HHV1-5, AAV and HPV DNAs in the semen samples. Of 145 samples, 66 (45.5%) were positive at least for one of the viruses. The genome detection rate of HSV1/2, VZV, EBV, HCMV, AAV and HPV were zero, 2.8%, zero, 1.4%, 27.6% and 19.3%, respectively. Of 66 positive samples for these viruses, 6 (4.1% of all samples) were positive for two viruses simultaneously. Here no association was found between variations in semen parameters related to fertility and detection of VZV, HCMV, AAV and HPV DNA in semen samples. It should be noted that the prevalence of different viruses in semen, and their relevance to male infertility, differs significantly due to the genome extraction and amplification methods or due to a real variation between study populations and geographical regions.
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