It was shown that the reticular patterns appeared as hypofluorescent lesions on ICGA, closely abutting, but not overlying the large choroidal vessels. In eyes with reticular pseudodrusen, EDI OCT revealed an overall thinned choroid.

No abstract

"Quiescent" CNVs are sub-RPE CNVs secondary to AMD, showing absence of intraretinal/subretinal exudation on repeated OCT. "Quiescent" CNVs enlarge over time and may contribute to local reduced retinal sensitivity and metamorphopsia.

The frequency of stage changes over time suggest that reticular pseudodrusen are dynamic pathologic structures.

The peculiar confocal scanning laser ophthalmoscopy fundus imaging and tracked SD-OCT of reticular pseudodrusen suggest the presence of central lipofuscin-like retinal deposits localized above the retinal pigment epithelium. These findings give insights to other possible aspects of age-related retinal changes.

Eyes with reticular pseudodrusen present a greater extent of reduced sensitivity than eyes with typical drusen.

ABSTRACT.Purpose: The purpose of this study was to understand clinical significance of near-infrared reflectance (NIR), blue fundus autofluorescence (FAF) and nearinfrared autofluorescence (NIA) in dry age-related macular degeneration (AMD), by correlation with fluorescein angiography (FA) and cross-sectional spectral domain optical coherence tomography (SD OCT). Methods: We evaluated 110 eyes (62 patients, mean age: 64 ± 8 years) diagnosed with dry AMD between January 2010 and December 2010, which underwent NIR (k = 830 nm), FAF and FA (excitation k = 488 nm; emission k > 500 nm), NIA (excitation k = 787 nm; emission k > 800 nm), and simultaneous SD OCT scanning using a combined confocal scanning laser ophthalmoscope ⁄ SD OCT device (Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany). Results: Drusen showed variable increased ⁄ decreased NIR, FAF, NIA and FA, which corresponded to variable increased ⁄ decreased thickness of the retinal pigment epithelium (RPE) and possible presence of subretinal deposits on SD OCT. Geographic atrophy (GA) was present in 43 ⁄ 110 eyes (39.0%) and showed increased NIR and fluorescence (FA), absent FAF and NIA, and loss of RPE on SD OCT. The hyperautofluorescence of the GA margin was never larger in FAF than that in NIA, while in 16.2% of cases, it was larger in NIA than that in FAF and corresponded to mild choroidal hyperreflectivity on SD OCT. Conclusions: Simultaneous recording of SD OCT scans provided ultrastructural data for the evaluation of NIR, FAF, NIA and FA in dry AMD. Near-infrared autofluorescence might detect earlier than FAF areas of RPE cell loss at the GA margin.

Macular edema (ME) may complicate anterior,