Here, we show that RIP3-dependent necroptosis modulates post-ischaemic adverse remodelling in a mouse model of MI. This novel signalling pathway may thus be an attractive target for future therapies that aim to limit the adverse consequences of myocardial ischaemia.

Facilitating research and enhancing community research capacity through a partnered approach in Inuit Nunangat (the Inuit homeland of Canada, located in Arctic Canada) presents learning opportunities and challenges for southern-based, non-Inuit researchers and community members alike. This article outlines lessons learned through the Arctic Corridors and Northern Voices (AC-NV) project, which involved 14 communities across Inuit Nunangat. The AC-NV focused on understanding community-identified impacts and potential management options of increased shipping in Inuit Nunangat due to sea ice reductions and a changing climate. The approach used to conduct the research involved visiting researchers and community partners working together with local organizations, and training and hiring northern youth as cultural liaisons and workshop co-facilitators. We strove to develop a model of collaborative partnership and strong north-south research relationships. In this paper, we draw on our broad learning experiences from four community case studies conducted as part of the AC-NV project: Arviat, Cambridge Bay, Gjoa Haven, and Pond Inlet, Nunavut. Close partnerships were formed in each of these communities, and 32 youth were trained in participatory mapping and workshop facilitation. For our diverse team of Inuit, northern- (i.e., non-Inuit, living in Inuit Nunangat), and southern-based non-Inuit researchers, our efforts to engage in partnered research were a critical component of the research and learning experience. In this article we share methodological reflections and lessons learned from what collaborative-partnered research means in practice. In so doing, we aim to contribute to the increasing dialogue and efforts around knowledge co-production and Inuit self-determination in research. Key conclusions of this reflective exercise include the importance of 1) conducting research that is relevant to local needs and interests, 2) visiting researchers and local organizations partnering together, 3) co-creating and refining knowledge documentation tools, 4) including youth cultural liaisons as co-facilitators, 5) conducting results validation and sharing exercises, and 6) being open to forming personal friendships. For the AC-NV, this community-based partnership approach resulted in more robust research results, strengthened north-south relations, and enhanced local capacity for community-led projects.

No abstract

There may have been a sampling issue, as the study compared patients from a specialist clinic for the treatment of OCD and Panic disorder. Furthermore, OCD referrals were primary, secondary, or tertiary, whereas Panic disorder referrals were primary or secondary from the immediate catchment area only. This suggests the possibility of greater severity of the OCD sample relative to Panic disorder patients. All participants who met criteria for OCD were assessed for OCPD regardless of whether or not this was indicated by the SCID II screener self-report measure, while participants with Panic disorder were interviewed for OCPD only if indicated by the SCID-II screener. Had participants with Panic disorder been assessed for OCPD regardless of whether or not this was indicated by the SCID-II screener, there is a possibility that a higher rate of OCPD in the Panic disorder sample may have been found.

As Inuit hunters living in Pond Inlet, Nunavut, we (Natasha Simonee and Jayko Alooloo) travel extensively on land, water, and sea ice. Climate change, including changing sea ice and increasingly unpredictable weather patterns, has made it riskier and harder for us to travel and hunt safely. Inuit knowledge supporting safe travel is also changing and shared less between generations. We increasingly use online weather, marine, and ice products to develop locally relevant forecasts. This helps us to make decisions according to wind, waves, precipitation, visibility, sea ice conditions, and floe edge location. We apply our forecasts and share them with fellow community members to support safe travel. In this paper, we share the approach we developed from over a decade of systematically and critically assessing forecasting products such as: Windy.com; weather and marine forecasts; tide tables; C-CORE’s floe edge monitoring service; SmartICE; ZoomEarth; and time lapse cameras. We describe the strengths and challenges we face when accessing, interpreting, and applying each product throughout different seasons. Our analysis highlights a disconnect between available products and local needs. This disconnect can be overcome by service providers adjusting services to include: more seasonal and real-time information, non-technical language, familiar units of measurement, data size proportional to internet access cost and speed, and clear relationships between weather/marine/ice information and safe travel. Our findings have potential relevance in the Circumpolar Arctic and beyond, wherever people combine Indigenous weather forecasting methods and online information for decision-making. We encourage service providers to improve product relevance and accessibility.