Objective:To investigate the medicative effects of medium-polar (benzene:acetone, 1:1, v/v) extract of leaves from Stevia rebaudiana (family Asteraceae) on alloxan-induced diabetic rats.Materials and Methods:Diabetes was induced in adult albino Wistar rats by intraperitoneal (i.p.) injection of alloxan (180 mg/kg). Medium-polar extract was administered orally at daily dose of 200 and 400 mg/kg body wt. basis for 10 days. The control group received normal saline (0.9%) for the same duration. Glibenclamide was used as positive control reference drug against Stevia extract.Results:Medium-polar leaf extract of S. rebaudiana (200 and 400 mg/kg) produced a delayed but significant (P < 0.01) decrease in the blood glucose level, without producing condition of hypoglycemia after treatment, together with lesser loss in the body weight as compared with standard positive control drug glibenclamide.Conclusions:Treatment of diabetes with sulfonylurea drugs (glibenclamide) causes hypoglycemia followed by greater reduction in body weight, which are the most worrisome effects of these drugs. Stevia extract was found to antagonize the necrotic action of alloxan and thus had a re-vitalizing effect on β-cells of pancreas.

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Aims: The aim of the present work to perform phytochemical screening and wound healing activity of different leaf extract of Rhynchosia rothii. Place and Duration of the Study: The present work has been carried out at Oriental University, Indore between the duration of November-2020 to January-2021. Methodology: Rhynchosia rothii dried leaf powder was subjected to continuous extraction with a soxhlet extractor using various organic solvents. Preliminary phytochemical screening with various qualitative chemical tests revealed the presence of Alkaloids, Tannins, Flavonoids, proteins, and mucilage present in Rhynchosia rothii leaf extracts. Wister rats of both sexes weighing 150-200 g were used for experimental purposes. The animals were kept in polypropylene cages at room temperature and with a light/dark cycle of 12:12 hours.  All the test extracts at a different dose level and standard were administered topically once daily from day 0 to the day of complete healing or the 21st postoperative day, whichever occurred earlier. Results: A significant increase in wound healing activity was observed in animals treated with alcoholic and aqueous extracts of Rhynchosia rothii leaves at a dose of 200 mg/kg body weight, compared to control treatments. Both methanolic and standard extracts of Rhynchosia rothii (200 mg/kg body weight) showed a dose-dependent increase in the rate of wound contraction. The methanolic extract of Rhynchosia rothii at a dose of 200 mg/kg body weight showed an increase in the percentage of wound contraction from 40.08% to 88.90% from day 3 to 12. The aqueous (standard) extract of Rhynchosia rothii at a dose of 200 mg/kg body weight showed an increase in the percentage of wound contraction from 46.02% to 100% from day 3 to 12. Conclusion: From the previous results it was concluded that the Wound represents a serious health problem, both in terms of morbidity and mortality. Wound healing is a critical response to tissue integrity. Therefore, the wound healing property of Rhynchosia rothii can be attributed to the phytoconstituents present in it, which may be due to its individual or additive effect that accelerates the wound healing process. Since Rhynchosia rothii is grown in abundance in India and rest of other part of world, it could be a fairly good and easily available therapeutic agent due to its naturally occurring tendency for healing wounds as a healer, as well as controlling abnormal healing.

The present study was undertaken to clarify whether methanolic extract of Tridax procumbens prevents liver fibrosis in rat. The hepatic fibrosis was induced by 28 days of bile duct ligation in rats. The 4-week treatment with Tridex procumbens reduced the serum aspartate aminotransferase (U L⁻¹), glutamate pyruvate transaminase (U L⁻¹), alkaline phosphatase (IU L⁻¹), lactate dehydrogenase (IU L⁻¹), total bilirubin (mg dL⁻¹), direct bilirubin (mg dL⁻¹) and hydroxyproline (mg gm⁻¹) content in liver and improved the histological appearance of liver section. The results of this study led us to conclude that T. procumbens can reduce the degree of hepatocellular damage and may become antifibrotic agent for liver fibrosis.