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In this study, the effects of three non-steroidal anti-inflammatory drugs, alclofenac, diclofenac and tiaprofenic acid, on the plasma level of sulfamethizole were investigated in rats. The persistence of sulfamethizole in plasma was prolonged by coadministration of each anti-inflammatory drug. In experiments to investigate the renal excretion of sulfamethizole, the clearance ratio of sulfamethizole was markedly decreased after infusion of each anti-inflammatory drug. From these results, it is speculated that prolongation of the persistence of sulfamethizole in plasma by alclofenac, diclofenac or tiaprofenic acid is mainly caused by competitive interactions between sulfamethizole and alclofenac, diclofenac or tiaprofenic acid at the renal secretory level.