Study of the interactions between sulfamethizole and three anti-inflammatory propionic acid derivatives at the renal level in rats.

Chiba, Kazumoto; Nishimura, Seikun; Kikuchi, Satoshi; Higuchi, Naoyo; Miyazaki, Shôzo

doi:10.1248/cpb.33.5100

Cited by 4 publications

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“…Our findings are consistent with those of Chiba et al (1985) who found a differential effect of various NSAID on the renal tubular secretion of sulphamethiazole in the rat. Ketoprofen and fenbufen significantly depressed the renal clearance of sulphamethiazole while FLU had no effect.…”

Section: Discussionsupporting

confidence: 93%

Differential effects of flurbiprofen and aspirin on acetazolamide disposition in humans.

Sweeney

Chapron

Antal

et al. 1989

Brit J Clinical Pharma

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The plasma concentration‐time profile of acetazolamide (AZ) following an intravenous bolus dose (5 mg kg‐1) was determined during control, aspirin and flurbiprofen (FLU) treatment periods. The unbound fraction of AZ in plasma increased three‐fold in the presence of salicylate (SA) while, in contrast, FLU produced consistent, but statistically insignificant, increases in binding. SA caused a two‐fold decrease in both unbound AZ renal clearance and apparent volume of distribution at steady‐state, while FLU produced a small, but significant, increase only in the latter. The area under the concentration‐time curve for AZ in erythrocytes was increased by about 40% during SA treatment while FLU had no effect. Our results suggest that on a pharmacokinetic basis FLU may be a safer nonsteroidal anti‐inflammatory drug (NSAID) to co‐ administer with AZ.

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Section: Discussionsupporting

confidence: 93%

Differential effects of flurbiprofen and aspirin on acetazolamide disposition in humans.

Sweeney

Chapron

Antal

et al. 1989

Brit J Clinical Pharma

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“…[3][4][5][6] In this paper, we deal with the interactions between sulfamethizole (SMZ) and ibufenac, sulindac or mepirizole at the renal level in rats, examined by the renal clearance technique. Furthermore, the correlation between the chemical structures of some NSAI drugs and the characteristics of the renal tubular transport is discussed.…”

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confidence: 99%

Comparative study of the interaction between sulfamethizole and ibufenac, sulindac or mepirizole at the renal level in rats.

Chiba

Kikuchi

Mino

et al. 1987

CHEMICAL & PHARMACEUTICAL BULLETIN

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The effects of three non-steroidal anti-inflammatory drugs, ibufenac, sulindac and mepirizole, on the renal excretion of sulfamethizole in rats were investigated, in order to clarify the mechanisms involved. The clearance ratio of sulfamethizole was markedly decreased after infusion of ibufenac, while sulindac or mepirizole had no effect on the clearance ratio of sulfamethizole. From this result, it is speculated that the decrease of renal excretion of sulfamethizole caused by ibufenac is mainly due to competitive interaction between sulfamethizole and ibufenac at the renal secretory level. The correlation between the chemical structures of some anionic non-steroidal anti-inflammatory drugs and the characteristics of renal tubular transport is discussed.

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A Possible Reduction in the Renal Clearance of Ciprofloxacin by Fenbufen in Rats

Naora

Katagiri

Ichikawa

et al. 1990

Journal of Pharmacy and Pharmacology

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The change in plasma concentration-time profile, serum protein binding and renal and biliary clearances of ciprofloxacin caused by coadministration of fenbufen has been studied in rats administered an intravenous dose of ciprofloxacin (5 mg kg-1) alone or with fenbufen (10 mg kg-1). Coadministered fenbufen significantly prolonged the plasma elimination half-life of ciprofloxacin from 40.5 to 57.6 min and tended to reduce the total body clearance of this quinolone by about 20%. The extent of ciprofloxacin binding to rat serum protein was not affected by fenbufen, nor did it affect the biliary clearance of the quinolone. However, fenbufen tended to reduce renal clearance and significantly decreased the cumulative renal excretion of the quinolone during at least the first 3 h after drug administration. These results suggest a possible reduction of ciprofloxacin clearance owing to inhibition of renal excretion by fenbufen.

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Study of the interactions between sulfamethizole and three anti-inflammatory propionic acid derivatives at the renal level in rats.

Cited by 4 publications

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Differential effects of flurbiprofen and aspirin on acetazolamide disposition in humans.

Differential effects of flurbiprofen and aspirin on acetazolamide disposition in humans.

Comparative study of the interaction between sulfamethizole and ibufenac, sulindac or mepirizole at the renal level in rats.

A Possible Reduction in the Renal Clearance of Ciprofloxacin by Fenbufen in Rats

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