Comparative study of interactions between 4-biphenylacetic acid and sulfamethizole, and between fenbufen and sulfamethizole in rats.

Chiba, Kazumoto; Kikuchi, Satoshi; Higuchi, Naoyo; Miyazaki, Shôzo

doi:10.1248/cpb.34.4389

CHEMICAL & PHARMACEUTICAL BULLETIN

1986

DOI: 10.1248/cpb.34.4389

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Comparative study of interactions between 4-biphenylacetic acid and sulfamethizole, and between fenbufen and sulfamethizole in rats.

Kazumoto Chiba¹,

Satoshi Kikuchi²,

Naoyo Higuchi³

et al.

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1987

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Cited by 2 publications

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“…[3][4][5][6] In this paper, we deal with the interactions between sulfamethizole (SMZ) and ibufenac, sulindac or mepirizole at the renal level in rats, examined by the renal clearance technique. Furthermore, the correlation between the chemical structures of some NSAI drugs and the characteristics of the renal tubular transport is discussed.…”

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Comparative study of the interaction between sulfamethizole and ibufenac, sulindac or mepirizole at the renal level in rats.

Chiba

Kikuchi

Mino

et al. 1987

CHEMICAL & PHARMACEUTICAL BULLETIN

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The effects of three non-steroidal anti-inflammatory drugs, ibufenac, sulindac and mepirizole, on the renal excretion of sulfamethizole in rats were investigated, in order to clarify the mechanisms involved. The clearance ratio of sulfamethizole was markedly decreased after infusion of ibufenac, while sulindac or mepirizole had no effect on the clearance ratio of sulfamethizole. From this result, it is speculated that the decrease of renal excretion of sulfamethizole caused by ibufenac is mainly due to competitive interaction between sulfamethizole and ibufenac at the renal secretory level. The correlation between the chemical structures of some anionic non-steroidal anti-inflammatory drugs and the characteristics of renal tubular transport is discussed.

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Comparative study of the interaction between sulfamethizole and ibufenac, sulindac or mepirizole at the renal level in rats.

Chiba

Kikuchi

Mino

et al. 1987

CHEMICAL & PHARMACEUTICAL BULLETIN

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A minor possibility of pharmacokinetic interaction between enoxacin and fenbufen in rats.

Naora

Katagiri²,

Ichikawa³

et al. 1990

Journal of Pharmacobio-Dynamics

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Comparative study of interactions between 4-biphenylacetic acid and sulfamethizole, and between fenbufen and sulfamethizole in rats.

Cited by 2 publications

References 0 publications

Comparative study of the interaction between sulfamethizole and ibufenac, sulindac or mepirizole at the renal level in rats.

Comparative study of the interaction between sulfamethizole and ibufenac, sulindac or mepirizole at the renal level in rats.

A minor possibility of pharmacokinetic interaction between enoxacin and fenbufen in rats.

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