Background Aortic stenosis (AS) is a progressive disease, with no pharmacological treatment. The prevalence of diabetes mellitus (DM) among AS patients is higher than in the general population. DM significantly increases the risk of AS development and progression from mild to severe. The interplay between AS and DM's mechanism is not entirely known yet. Main Body The increased accumulation of advanced glycation end products (AGEs) was linked to increased valvular oxidative stress, inflammation, expression of coagulation factors, and signs of calcification, according to an analysis of aortic stenotic valves. It is interesting to note that in diabetic AS patients, valvular inflammation did not correlate with serum glucose levels but rather only with long-term glycemic management markers like glycated haemoglobin and fructosamine. Transcatheter aortic valve replacement, which has been shown to be safer than surgical aortic valve replacement, is advantageous for AS patients who also have concurrent diabetes. Additionally, novel anti-diabetic medications have been proposed to lower the risk of AS development in DM patients, including sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonist that target reduction of AGEs-mediated oxidative stress. Conclusions There are little data on the effects of hyperglycemia on valvular calcification, but understanding the interactions between them is essential to develop a successful treatment strategy to stop or at least slow the progression of AS in DM patients. There is a link among AS and DM and that DM negatively impacts the quality of life and longevity of AS patients. The sole successful treatment, despite ongoing efforts to find new therapeutic modalities, involves aortic valve replacement. More research is required to find methods that can slow the advancement of these conditions, enhancing the prognosis and course of people with AS and DM. Graphical Abstract
Background This review aims to describe existing evidence on the state of hypertension in Pakistan, including the prevalence, associated risk factors, preventive strategies, and challenges in the management of hypertension. Methods A comprehensive literature search was conducted electronically using PubMed and Google Scholar. Using specific screening methodology, 55 articles were selected to be included. Results We found from this extensive review that several small studies report high prevalence of hypertension but there is a lack of population based prevalence of hypertension in Pakistan. Lifestyle risk factors such as obesity, unhealthy diet, decreased physical activity, low socioeconomic status, and lack of access to care were the main associated factors with hypertension. Lack of blood pressure monitoring practices and medication non-adherence were also linked to uncontrolled hypertension in Pakistan and were more evident in primary care setups. The evidence presented is essential for delineating the burden of the disease, hence allowing for better management of this underserved population. Conclusion There is a need for updated surveys to depict the true prevalence and management of hypertension in Pakistan. Cost-effective implementation strategies and policies at the national level are needed for both prevention and control of hypertension.
Phyllanthus emblica (Linn.) is a common plant and fruits very popular in Bangladesh. It is a common ingredient of many traditional and herbal medicines. The intention of the present study was to explore the scientific relation with the traditional use of the fruit of Phyllanthus emblica (Linn.). Antimicrobial screening, analgesic activity, antidiarrheal activity and the brine shrimp lethality test for cytotoxic activity screening are the selected pharmacological activities. Phytochemical analysis of ethanolic fruits extract confirms that the fruit contain flavonoids, alkaloids, tannin, steroids, reducing sugar and gum. Experimental screening confirms that the fruit extract produced 19.07% and 38.67% writhing inhibition at the oral dose of 250 and 500mg/kg-body weights respectively. That means ethanol extract of the fruit of Phyllanthus emblica (Linn.) has an analgesic property. The ethanolic fruit extract of Phyllanthus emblica (Linn.) also significantly inhibited ear edema formation in xylene induced ear edema, considered as direct evidence that supporting the anti-inflammatory activity of ethanolic fruit extract of Phyllanthus emblica (Linn.
Background One of the most important healthcare challenges in the world today is neurological disorders. Pose lifestyle changes are linked to a significantly higher risk of chronic illnesses and diseases, placing a significant financial and healthcare burden on society at large. In this review article, we focused on the various neuro-nutraceutical herbs and their beneficial roles in neurodegenerative disorders. Main body of the abstract An extensive literature review was done from the standard databases such as Scopus, Elsevier, and PubMed using standard keywords “Nutraceuticals”, “Neuro-nutraceuticals”, “Neurodegenerative disorders”. Numerous "neuro-nutraceuticals" are natural plant compounds with dietary and pharmaceutical components that are intended to improve cerebral blood flow along with illness prevention and control. These compounds are found in food, herbal medicines, and nutritional supplements such as Bacopa monnieri, Curcuma longa, Asparagus racemosus, Helicteres angustifolia, Hericium erinaceus, Crocus sativus, Uncaria tomentosa, Centella asiatica, Convolvulus pluricaulis, Moringa oleifera. Short conclusion While discussing the neuroprotective and the neuromodulatory properties of various neuro-nutraceuticals, we rationally postulate here their molecular mechanisms. Additionally, compared to single-target medicines, which may have unfavourable side effects, these herbs are believed to be safer and to provide a more holistic improvement in brain health. Graphical Abstract
Background: The COVID-19 virus has had a great effect globally, changing many commonalities. The incidence of COVID-19 had weakened the immune system, leading to more severe outcomes of various common diseases. Since its early development, the vaccination of COVID-19 has also had mixed responses. The aim of the study was to observe the incidence rate of COVID-19 infection and vaccination status among chronic kidney disease patients. Methods: In this study 50 (27 male and 23 female) adult skulls were investigated to determine the type of asterion, its distance from important bony landmarks and also the nearby venous sinuses were measured. Results: Majority (41.61%) of the participants had been between the ages of 41-55 years old, and 64.84% male prevalence was observed. 60.65% of the participants had been from rural areas. A large portion of the participants (38.06%) did not have any comorbidities, while multiple comorbidities were present among many of the remaining participants. Hypertension was the most common comorbidity, observed in 56.45% of the participants. 72.26% of the present study participants had been asymptomatic, while 13.23% had a fever as their symptom of COVID-19. COVID-19 test was done on 81 patients, among whom 64 had tested positive. Among the total 310 participants, 29.03% had not received any vaccinations, while 14.19% had received only 1st dose of vaccination, 47.2% had received up to their 2nd dose, and 9.35% had received their booster dose. Conclusions: The present study observed a low incidence rate of COVID-19 positive patients among those affected by chronic kidney disease. However, the study also observed a significant positive relation between COVID-19 positive patients and the need for additional medical support, leading to the conclusion that COVID-19 can significantly affect the severity of CKD.
Acute myocardial infarction is an event of myocardial necrosis caused by unstable ischemic syndrome. Myocardial infarction (MI) occurs when blood stops flowing to the cardiac tissue or myocardium and the heart muscle gets damaged due to poor perfusion and reduced oxygen supply. Mitochondria can serve as the arbiter of cell fate in response to stress. Oxidative metabolism is the function of mitochondria within the cell. Cardiac cells being highly oxidative tissue generates about 90% of their energy through oxidative metabolism. In this review, we focused on the role of mitochondria in energy generation in myocytes as well as its consequences on heart cells causing cell damage. The role of mitochondrial dysfunction due to oxidative stress, production of reactive oxygen species, and anaerobic production of lactate as a failure of oxidative metabolism are also discussed
Incidences of Diabetes mellitus (DM) gets worsen on frequent long-haul travel in different time zones and sedentary lifestyle. An extensive review of the published articles related to diabetes, the effect of lifestyle modification (exercise and diet) and travelling of diabetic people across different time zones were done and these were accessed from Pubmed-Medline, Web of Science, Cochrane Library, EMBASE, Lancet and Diabetes Care. The study done by different scientists were compared and interpreted for the worsening of cases of DM. For long-haul travel in different time zones, it was observed that, due to metabolic disturbances, serious consequences of DM were observed in flight, but that can be prevented if pre-advice are taken by the patients and strictly followed. The cumulative incidences of diabetes of 10 cases were compared and mean cumulative incidences of control group (following sedentary lifestyle) was 42.77% and of intervention group (following healthy diet and moderate physical activity) was 22.11% confirming that implementation of the healthy diet and exercise as regular physical activity caused the lowering of cumulative incidences of diabetes. According to the research conducted on frequent flyers and sedentary lifestyle, the hypothesis quoted by various scientists is that DM is a metabolic disorder which easily gets affected by the frequent changes in the metabolism leading to its high incidences. Thus, the concept of chronobiology comes into light that requires more research to correlate the disturbed biological rhythm (Circadian cycle) to the incidences and severity of DM condition (worsening or increased incidences of DM).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.