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Objective: To investigate occur the histomatrical alternations in placental terminal villi and their vessels of Iraqi diabetes (gestational diabetes and overt diabetes) and normal pregnancies were born male and female neonates. Methods: The hitometrical study of male and female terminal villi of 68 placentae in maternal diabetes mellitus (34 gestational diabetes, 34 overt diabetes (17 DM type 1 and 17 DM type 2) and 34 normal placentae. These placentae obtained from Department of Obstetrics and Gynaecology in three hospitals in Baghdad city. Results: The study showed that there is a statistically significant with higher diameter in central and peripheral sections of the terminal villi and their vessels in male neonate. Moreover, terminal villous diameter in central and peripheral sections of placentae in both male and female neonates appeared highly significant differences (P≤0.001) between DM type 1 and DM type 2, but fetal blood vessels in this terminal villous did not record any significant difference (P>0.05). Conclusions: The current results concluded that increasing in diameters terminal villous and their fetal blood vessels of central and peripheral sections of placentae recorded increasing diameters of GDM peripheral sections of placentae in male neonate in comparison to placental sections of other study groups.

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The new antiepileptic drugs, levetiracetam (LEV), are used to treat tonic-clonic seizures and myoclonic seizures in adults and children. Thirty pregnant rats were enrolled, which were divided into two groups A control (10), B treated (20). Group (A) were given distilled water orally for 15 days of pregnancy period. The other group was subdivided into two subgroups B1, B2 (each with 10 rats), which were treated with LEV for 14 days for subgroup (B1) and 15 days for the other subgroup (B2). The drug (350 mg/kg/day) is administered orally. Based on our results there was damage in the kidney due to the toxicity of the drug. The histopathological effects is represented by damage of cortical glomeruli in which there were hemorrhage, shrinking, accumulation of glomerular cells, and enlargement of capsular space.  Severe malformations in the kidney were observed when the drug is used constantly during the organogenesis stages of pregnancy.