The i n -v i t r o r e l e a s e o f Naproxen from v a r i o u s o i n t m e n t b a s e s , i n c l u d i n g a w a t e r -w a s h a b l e b a s e w i t h t h e d r u g i n t h e water p h a s e ( I ) and t h e d r u g i n t h e o i l p h a s e (11). a h y d r o p h i l i c base w i t h t h e d r u g i n t h e water p h a s e (111). a n d t h e d r u g i n t h e o i l p h a s e (IV), and a n a n h y d r o u s o i n t m e n t (V), a g e l (VI) a n d a m o d i f i e d U n i v e r s i t y o f C a l i f o r n i a ( U . C . H . ) b a s e (VII) were s t u d i e d . I n a d d i t i o n , t h e e f f e c t s o f v a r i o u s a d d i t i v e s ( u r e a , e t h a n o l , d i m e t h y l s u l f o x i d e a n d p o l y e t h y l e n e g l y c o l -4 0 0 ) on t h e release o f Naproxen from f o r m u l a t i o n s (I) a n d ( 1 1 ) were d e t e r m i n e d . Low c o n c e n t r a t i o n s o f u r e a a n d e t h a n o l i n t h e f o r m u l a t i o n s i n c r e a s e d t h e release o f t h e d r u g from b o t h t h e s e b a s e s , however, h i g h e r c o n c e n t r a t i o n s a d v e r s e l y a f f e c t e d t h e release of t h e d r u g . While d i m e t h y l s u l f o x i d e (DMSO) had no s i g n i f i c a n t e f f e c t o n t h e d r u g r e l e a s e , t h e i n c l u s i o n o f p o l y e t h y l e n e g l y c o l -4 0 0 i n b o t h b a s e s d e c r e a s e d t h e release o f Naproxen. The p e r c u t a n e o u s a b s o r p t i o n o f Naproxen from t h e waterw a s h a b l e base ( d r u g i n t h e oil p h a s e ) a n d h y d r o p h i l i c b a s e ( d r u g i n t h e o i l p h a s e ) were s t u d i e d by a p p l y i n g t h e o i n t m e n t s o n 651 Copyright 0 1990 by Marcel Dekker, Inc. Drug Dev Ind Pharm Downloaded from informahealthcare.com by TIB/UB Hannover on 01/03/15 For personal use only. 652 RAHMAN ET AL.rabbit's skin. It was observed that the bioavailability of Naproxen from the hydrophilic base was slightly greater than that from the water-washable base, and that DMSO had no effect in enhancing the in-vivo release of Naproxen from the ointments evaluated. Using the in-vivo data, the absorption and elimination rate constants, the half-life and AUC were calculated. Drug Dev Ind Pharm Downloaded from informahealthcare.com by TIB/UB Hannover on 01/03/15 For personal use only. Drug Dev Ind Pharm Downloaded from informahealthcare.com by TIB/UB Hannover on 01/03/15 For personal use only.
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