Introduction: Androgenetic alopecia (AGA) is hereditary and androgen dependent, progressive thinning of the scalp hair that follows a defined pattern. Aim ot the work: is to evaluate the efficacy and safety of mesotherapy using dutasteride in treatment of androgenetic alopecia in males. Materials and Methods: Ninety male patients were randomly assigned into three groups; group A containing 30 patients who received pure dutasteride, group B of another 30 patients who received dutasteride containing solution and group C of the remaining 30 patients who received saline. Each group was given nine mesotherapy sessions. Assessment was done using trichogram, independent observer assessment of photographs and patients self assessment together with evaluation of possible systemic absorption using semenogram and serum dihydrotestosterone (DHT). Result: Statistical analysis of the thrichogram results, the effect on semenogram and the serum level of dihydrotestosterone.showed that dutastride containing solution was the best. Conclusion: Mesotherapy using dutasteride is a good option for treatment of male pattern hair loss; resulting in reduction or cessation of hair loss and promotion of new hair growth. : Evaluation of the effect of injection of dutasteride as mesotherapeutic tool in treatment of androgenetic alopecia in males. Our Dermatol Online. 2013; 4(1): 40-45

CA-MRSA must be considered when treating skin and soft tissue infections, especially in developing countries. Empirical use of agents active against CA-MRSA is warranted for patients presenting with serious SSTIs.

To date, the genes associated with susceptibility to Atopic Eczema (AE) are mainly implicated in immunity, inflammation, and maintenance of skin barrier. Little is known about the possible relationship between genes modulating Extra-Cellular Matrix (ECM) and AE etiopathogenesis. In this regard, the primary objective of the present study has been the investigation of susceptibility biomarkers localized within genes encoding collagen proteins. Several studies have shown that polymorphisms within the genes encoding such proteins may generate abnormal connective tissues, making them more susceptible to mechanical stress, loss of epidermal integrity, and aging. We therefore decided to investigate three polymorphisms located in COL6A5, COL8A1, and COL10A1 as potential susceptibility biomarkers for AE in a cohort of 1470 subjects of Mediterranean origin. The genes of interest have been selected considering that the ECM and immune/inflammatory response are strongly dysregulated in AE and other complex disorders. The study confirmed that the susceptibility to AE depends on a complex interaction between latitude, geographical localization, and the differential distribution of genetic variants among populations exposed to similar environmental factors.

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Introduction: Transplantation of Autologous non-cultured melanocytes suspension is a simple yet effective cell-based therapy for vitiligo. Materials and Methods: 20 patients with stable vitiligo were subjected to epidermal cell suspension transplantation using Osslon's method with some new modifications. Result: The repigmentation at 7 of the test sites (35.0%) was excellent. It was good for more than half of the test sites (55.0%). Fair repigmentation was encountered among only 2 (10.0%) of the tested sites. None of the tested sites showed poor repigmentation. On the other hand, none of the control sites showed excellent or even good repigmentation. However, repigmentation was fair for nearly 10% and it was poor for 90% of the control sites. Conclusion: Autologus non cultured basal -enriched epidermal cell suspension transplantation is an effective, simple and safe method for treatment of stable vitiligo.

BACKGROUND Palmar hyperhidrosis is a common disorder of excessive sweating due to over-stimulation of cholinergic receptors on eccrine glands. OBJECTIVE To compare the efficacy of laser-assisted drug delivery of onabotulinum toxin A (BoNTA) and intradermal BoNTA injections in the management of palmar hyperhidrosis. PATIENTS AND METHODS This intrapatient comparative study was conducted on 30 adult patients with idiopathic palmar hyperhidrosis. The palms of the patients were divided into 2 groups. Group 1 was treated with intradermal injections of 50 units of BoNTA, whereas Group 2 was subjected to laser-assisted transcutaneous BoNTA delivery using fractional CO 2 laser at different doses (25, 50, and 75 units). Each treatment modality was evaluated using the iodine starch test, hyperhidrosis disease severity scale, and gravimetric scoring. RESULTS Delivery of 75 units of BoNTA to the dermis on the right-sided palms assisted by fractional CO 2 laser was clinically equivalent to 50 units of injection on the left side. Pain intensity was significantly higher on the injected side than on the other side. CONCLUSION Laser-assisted drug delivery of botulinum toxin can be considered an effective and safe alternative for treatment of palmar hyperhidrosis with minimal side effects and complications.

Introduction: Ablative, fractional lasers generate microscopic columns of coagulated tissue through the epidermis and dermis to evoke a wound healing response. In this study, we examined the efficacy and safety of fractional ablative 2940nm erbium: YAG laser in the treatment of surgical and post-traumatic scars. Fractional laser photothermolysis is the latest in the broad range of Er: YAG laser technique. This technique promises a novel means of providing treatments that would be as effective as traditional Er: YAG, while further reducing their down time and risk. Aim of the Work: The aim of this work is to assess the efficacy and safety of variable square pulse (VSP) fractional Er: YAG laser for the treatment of surgical and post-traumatic scars; both clinically and histopathologically. Methods: Clinical studies were conducted on a range of surgical and post-traumatic scars with a 2940nm erbium: YAG fractional ablative laser varying energy, pulse widths, treatment passes, and number of treatments: twenty subjects, with Fitzpatrick skin types III-IV, received two to five treatments at one month interval and a follow up period for 3 months. Clinical and histopathological evaluation of the results was performed. Results: Almost all patients improved both clinically and histopathologically. Clinical improvement in scars according to investigator assessment: 40% of patients had excellent improvement of 76-100% (grade 3), 50% of patients had good improvement of 50-75% (grade 2), 10% had fair improvement of 26-49% (grade 1) at three month follow up. Histologic findings demonstrated remodeling of scar tissue with renewal and reorganization of collagen fibers in the dermis was noted two weeks post-treatment. Conclusion: These data illustrate the safety and efficacy of the 2940nm erbium:YAG fractional ablative laser in the treatment of surgical and post-traumatic scars with short down time period, and almost no incidence of complication. StreszczenieWstęp: Ablacyjne lasery frakcyjne generują mikroskopijne kolumny poprzez koagulację tkanek naskórka i skóry właściwej wywołując reakcję gojenia ran. W tym badaniu zbadaliśmy skuteczność i bezpieczeństwo frakcyjnego ablacyjnego lasera erbowego 2940nm: YAG w leczeniu blizn chirurgicznych i pourazowych. Frakcyjna laserowa fototermoliza jest ostatnio techniką o szerokim zakresie Er: YAG. Technika ta obiecuje nowy sposób świadczenia zabiegów, które byłyby tak samo skuteczne jak tradycyjne Er: YAG, przy jednoczesnym zmniejszeniu ich czasu i ryzyka. Cel pracy: Celem niniejszej pracy jest ocena skuteczności i bezpieczeństwa stosowania zmiennego kwadratowego impulsu (VSP) frakcyjnego lasera Er: YAG do leczenia blizn chirurgicznych i pourazowych, zarówno pod względem klinicznym jak i histopatologicznym. Metody: Badania kliniczne prowadzone były w zakresie chirurgicznych i pourazowych blizn za pomocą frakcyjnego ablacyjnego lasera erbowego 2940nm: YAG różnej energii, szerokości impulsu, przebiegu leczenia i liczby zabiegów: dwudziestu pacjentów, z typami skóry Fitzpatrick III-IV...

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