Recently, administration of nicotinamide (NA) in a suitable dose before STZ administration was used for experimental induction of type 2 diabetes in rats. Injection of NA leading to partial beta-cells protection from necrosis resulted from STZ injection (Lee et al., 2010). This model may give beneficial tool especially for new insulinotropic agents' investigations (Madkor et al., 2011). The commonly anti-diabetic drug formerly used is metformin. It is used to treat T2DM (Alshathly, 2019). On contrary, hundreds of conventional folk medicines have been used to treat diabetes with less side effects and tolerability. Thus, there is an increasing need to search for more natural antidiabetic agents from traditional medicine. Zingiber officinale belongs to the family Zingiberaceae, has staring impending for treating a number of ailments including DM, cardiovascular, and digestive disorders, vomiting, and cancer (Mashhadi et al., 2013), because it contains more chemical compounds, such as (6)-gingerol, α-zingiberene, phenolic compounds, essential oils, and oleoresin resins (Kondeti Ramudu et al., 2011). Nigella sativa of the family Ranunculaceae is infamous to have valuable effects in the handling of lots of diseases and this correlated to plentiful active components which have been isolated from seeds and its oil including dithy
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