Assessment of Ameliorative Effects of Zingiber Officinale and Nigella sativa on Streptozotocin-induced Diabetic Rats

Abstract

Recently, administration of nicotinamide (NA) in a suitable dose before STZ administration was used for experimental induction of type 2 diabetes in rats. Injection of NA leading to partial beta-cells protection from necrosis resulted from STZ injection (Lee et al., 2010). This model may give beneficial tool especially for new insulinotropic agents' investigations (Madkor et al., 2011). The commonly anti-diabetic drug formerly used is metformin. It is used to treat T2DM (Alshathly, 2019). On contrary, hundreds of conventional folk medicines have been used to treat diabetes with less side effects and tolerability. Thus, there is an increasing need to search for more natural antidiabetic agents from traditional medicine. Zingiber officinale belongs to the family Zingiberaceae, has staring impending for treating a number of ailments including DM, cardiovascular, and digestive disorders, vomiting, and cancer (Mashhadi et al., 2013), because it contains more chemical compounds, such as (6)-gingerol, α-zingiberene, phenolic compounds, essential oils, and oleoresin resins (Kondeti Ramudu et al., 2011). Nigella sativa of the family Ranunculaceae is infamous to have valuable effects in the handling of lots of diseases and this correlated to plentiful active components which have been isolated from seeds and its oil including dithy

Explicit mechanistic insights of Prosopis juliflora extract in streptozotocin-induced diabetic rats at the molecular level

“…The present investigation found that STZ caused damage to Langerhans islets and -cells, as evidenced by the loss of their architecture and insulin antibody positivity, which is consistent with prior findings ( EL Baz et al, 2020 , Ibrahim et al, 2020 ). In diabetic rats, both histological and morphometrical evaluations revealed degenerative alterations in pancreatic islets, with a drop in the number of -cells/islet and a decrease in islet area compared to the control group.…”

Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)

“…Histologically, only a few samples showed pycnotic changes (early necrosis) in the pancreas. On the contrary, the rest of the tested samples showed an improvement in the number and morphology of islet cells, which were quite normal with a slight interstitial dilation of the blood vessels, and a slight perivascular dilation [ 103 ]. Regarding the glucose tolerance test, the methanolic extract at a dose of 500 mg/kg was able to decrease blood glucose.…”