The majority of MCM-related tweets by onsite and remote Twitter users were social in nature or pertained to educational sessions held over the course of the conference.
Several pharmacokinetic studies have suggested that dabigatran possesses a number of ideal properties for expedited removal via extracorporeal methods. However, this practice has not been prospectively evaluated in patients with life-threatening bleeding or requiring emergency surgery secondary to dabigatran-associated coagulopathy. The purpose of this literature review is to evaluate the published evidence surrounding extracorporeal removal of dabigatran in the setting of emergency surgery or life-threatening bleeding. A query of MEDLINE, Web of Science, International Pharmaceutical Abstracts, and Google Scholar using the terms dabigatran, dabigatran etexilate, hemodialysis, renal replacement therapy, hemorrhage, and atrial fibrillation was used to retrieve relevant literature. Furthermore, a manual search of the references of the identified literature was performed to capture additional data. Current evidence suggests that extracorporeal removal of dabigatran may play a role in the setting of life-threatening bleeding and emergent surgery. Conflicting evidence exists with regard to the potential for redistribution based on serum dabigatran concentrations. In addition, a number of practicalities must be considered before incorporating this technique in the clinical setting. Extracorporeal removal of dabigatran may be a treatment modality in selected patients who require emergency reversal.
Background The Food and Drug Administration issued a drug safety alert highlighting the potential association of docetaxel infusion with signs and symptoms of alcohol intoxication. This concern is significant because patients treated with docetaxel often have comorbidities and are prescribed concomitant centrally active medications. As a result, these patients may be at risk for iatrogenic events. Objective The objective of this study was to identify a correlation with docetaxel infusion and saliva ethanol concentration using a point-of-care ethanol test. Methods In this pilot study, ethanol concentrations were measured using a validated saliva ethanol test in patients receiving intravenous docetaxel as part of their chemotherapy regimen. Both ethanol dose and infusion rate were calculated based on the amount of the specific docetaxel product administered. Saliva ethanol concentrations were measured at baseline, immediately after infusion completion, and at 30 and 60 min postinfusion. Results A total of 17 patients were included in the analysis. The mean ethanol dose administered was 2.6 ± 0.5 g of ethanol per infusion of docetaxel with a mean infusion rate of 3.2 ± 0.7 ml of ethanol per hour. At baseline, immediately after infusion, and 30 and 60 min postinfusion, all patients had a saliva ethanol test result of 0 mg/dl. Conclusion Based on this small pilot study, the prediction of patients who will experience ethanol intoxication using a point-of-care saliva ethanol test based on the docetaxel dose administered is challenging. This observation requires confirmation in larger and more heterogeneous populations.
IntroductionSpecialties within the field of science, technology, engineering, and mathematics (STEM) have demonstrated that disparities exist within editorial boards of their respective professional journals. However, limited data of this observation exists within the scope of pharmacy practice. The purpose of this study was to evaluate the distribution of gender across editorial board members of several pharmacy journals.MethodsIn this cross‐sectional study, a total of 20 pharmacy journals were selected, using a combination of several factors including the SCImago Journal and Country Rank as of March 2019 and prominence across various organizations within the discipline. Publicly available information from the official website of each respective journal was evaluated to determine the proportion of males and females serving as members of the editorial board. An Internet search was conducted to confirm this demographic for those individuals where gender could not be determined. Descriptive statistics were used to quantify qualitative variables.ResultsData were sufficient to determine the gender of editorial members in all 20 pharmacy journals. Eight hundred and thirteen individuals were identified to serve on editorial boards, of which 326 (40%) were female, with a range of 8% to 63% per journal. Only four journals (20%) had a female editor‐in‐chief.ConclusionDisparities in gender distribution exist among editorial boards of pharmacy journals. Future efforts should focus on increasing the proportion of women serving as both members of the editorial board and as editor‐in‐chief to drive diversity, minimize implicit bias, and possibly enhance the content and quality of publications.
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