Background: disturbed physiological rhythm of blood pressure in preeclampsia is a common finding. The role of oxidative stress in pathogenesis of preeclampsia is well accepted. Melatonin is a powerful free radical scavenger so it's rapidly consumed by enhanced reactive oxygen species in preeclampsia causing non-dipping in blood pressure. Objective: To evaluate the change in plasma melatonin levels in patients with preeclampsia and its relationship with blood pressure. Patients and methods: In this prospective case control study a total of 40 primigravidae pregnant women were recruited during the period of 11 months between August 2015 and August 2016 in Baghdad teaching hospital, medical city, Iraq, divided into two groups: First groups: (cases group) were 20 primigravidae pregnant women with PE. Second group: (control group) were 20 normal healthy primigravidae. Blood Pressure measurement, melatonin blood samples were taken, plasma melatonin levels measurement was done by ELISA immunoassay. Urine was collected over 24 hours for protein in urine measurement. Results : Plasma Melatonin level in control , day and night was (22.72 ± 2.6 pg/mL) , (75.26 ± 2.99 pg/mL) compared to Plasma Melatonin level in dipper PE day and night (20.5±2.4 pg/mL) , (75.26 ± 1.8 pg/mL) which was statistically not significant(P value 0.055) , (P value 1.0) respectively. Plasma Melatonin level for non-dipper (22.45 ± 2.48 pg/mL) were similar to dipper (20.5±2.4 pg/mL) which is not significant (P value 0.1) , while Night time Plasma Melatonin of non-dipper (36.76 ± 1.27) were reduced when compared to control (75.26 ± 2.99 pg/mL) and to dipper group (75.26 ± 1.8 pg/mL) which was highly significant (p <0.0001 , p <0.0001) respectively. Conclusion: Night time Plasma Melatonin level reduced in Primigravid Women with preeclampsia that did not show nocturnal dipping in blood pressure.
In the present study, we evaluate the serum level of common autoimmunologic markers in women with polycystic ovary syndrome (PCOS) and study their relationship with hormonal parameters. The study was an observational case-control study, done in a Tertiary referral hospital, the study included 50 women with polycystic ovary syndrome and 50 matched control. Serum levels of Antinuclear Antibody (ANA) and anti-double-stranded DNA (dsDNA) were significantly higher in polycystic ovary syndrome women compared to control. Also, luteinizing hormone (LH), follicle stimulating hormone (FSH), and LH/FSH ratio were significantly higher in polycystic ovary syndrome women compared to control. dsDNA had excellent ability to differentiate PCOS from control (AUC=0.901) while ANA had good discrimination ability (AUC=0.809). There was a significant direct relationship between ANA, dsDNA, and TSH with FSH in PCOS women, also a significant direct relationship between ANA and TSH with LH, while DsDNA did not correlate with LH. In conclusion, there is a clear relationship between immunological markers (ANA, dsDNA) with polycystic ovary syndrome in various components of the disease, dsDNA offer better ability than ANA as a predictor of PCOS, indicating that dsDNA can be used as a non-invasive diagnostic tool for PCOS.
Background: disturbed physiological rhythm of blood pressure in preeclampsia is a common finding. The role of oxidative stress in pathogenesis of preeclampsia is well accepted. Melatonin is a powerful free radical scavenger so it's rapidly consumed by enhanced reactive oxygen species in preeclampsia causing non-dipping in blood pressure.Objective: To evaluate the change in plasma melatonin levels in patients with preeclampsia and its relationship with blood pressure.Patients and methods: In this prospective case control study a total of 40 primigravidae pregnant women were recruited during the period of 11 months between August 2015 and August 2016 in Baghdad teaching hospital, medical city, Iraq, divided into two groups:First groups: (cases group) were 20 primigravidae pregnant women with PE.Second group: (control group) were 20 normal healthy primigravidae.Blood Pressure measurement, melatonin blood samples were taken, plasma melatonin levels measurement was done by ELISA immunoassay. Urine was collected over 24 hours for protein in urine measurement.Results : Plasma Melatonin level in control , day and night was (22.72 ± 2.6 pg/mL ) , (75.26 ± 2.99 pg/mL ) compared to Plasma Melatonin level in dipper PE day and night (20.5±2.4 pg/mL ) , (75.26 ± 1.8 pg/mL) which was statistically not significant( P value 0.055 ) , (P value 1.0) respectively .Plasma Melatonin level for non-dipper ( 22.45 ± 2.48 pg/mL) were similar to dipper (20.5±2.4 pg/mL) which is not significant (P value 0.1) , while Night time Plasma Melatonin of non-dipper (36.76 ± 1.27 ) were reduced when compared to control (75.26 ± 2.99 pg/mL) and to dipper group (75.26 ± 1.8 pg/mL ) which was highly significant (p <0.0001 , p <0.0001) respectively .Conclusion: Night time Plasma Melatonin level reduced in Primigravid Women with preeclampsia that did not show nocturnal dipping in blood pressure.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.