Measuring of Plasma Melatonin Level in Patients with Preeclampsia

Shalal, Maad M.; Kadhim, Ishraq M.; Abbas, Nada S.; Abdulsattar, Ghaidaa

doi:10.32007/med.1936/jfacmedbagdad.v59i3.9

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…), obesity, diabetes mellitus, metabolic syndrome, endometriosis and polycystic ovary syndrome, as well as in women working at night [ 138 , 139 , 140 , 141 , 142 , 143 ]. It has been found that in such women pregnancies are complicated by chronic placental insufficiency, preeclampsia and gestational diabetes [ 144 , 145 , 146 , 147 ]. Numerous experimental and clinical studies provide evidence that in the case of preeclampsia there is no significant increase in epiphyseal melatonin (which is characteristic for noncomplicated pregnancies) and no melatonin circadian rhythm [ 88 , 139 , 148 ].…”

Section: The State Of the Placenta And Fetal Development In The Camentioning

confidence: 99%

Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis

Ivanov

Evsyukova

Mironova

et al. 2021

IJMS

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The review summarizes the results of experimental and clinical studies aimed at elucidating the causes and pathophysiological mechanisms of the development of endocrine pathology in children. The modern data on the role of epigenetic influences in the early ontogenesis of unfavorable factors that violate the patterns of the formation of regulatory mechanisms during periods of critical development of fetal organs and systems and contribute to the delayed development of pathological conditions are considered. The mechanisms of the participation of melatonin in the regulation of metabolic processes and the key role of maternal melatonin in the formation of the circadian system of regulation in the fetus and in the protection of the genetic program of its morphofunctional development during pregnancy complications are presented. Melatonin, by controlling DNA methylation and histone modification, prevents changes in gene expression that are directly related to the programming of endocrine pathology in offspring. Deficiency and absence of the circadian rhythm of maternal melatonin underlies violations of the genetic program for the development of hormonal and metabolic regulatory mechanisms of the functional systems of the child, which determines the programming and implementation of endocrine pathology in early ontogenesis, contributing to its development in later life. The significance of this factor in the pathophysiological mechanisms of endocrine disorders determines a new approach to risk assessment and timely prevention of offspring diseases even at the stage of family planning.

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