The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

Dou, Yuanyan; Lin, Binbin; Cheng, Hui; Wang, Changbao; Zhao, Mingming; Zhang, Jie; Wu, Jing

doi:10.1080/10641955.2019.1581215

Cited by 14 publications

(11 citation statements)

References 28 publications

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“…Maternal melatonin levels have been shown to be important for adequate fetal development ( Lanoix et al, 2012 ) due to the exposure to the maternal rhythms such as maternal melatonin, which crosses the placenta barrier unaltered ( Seron-Ferre et al, 1993 ). Complicated pregnancies are associated with a decrease in melatonin levels, thus indirectly affects the fetus with occurrence of intrauterine growth restriction ( Dou et al, 2019 ; Lanoix et al, 2012 ; Laste et al, 2021 ; Nakamura et al, 2001 ; Shimada et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin has beneficial roles in placental and fetal functions and are essential for successful pregnancy ( Lanoix et al, 2012 ; Shimada et al, 2016 ). In line with melatonin's important biological functions, a diminished maternal plasma and/or saliva melatonin levels are found in complicated pregnancies with preeclampsia ( Dou et al, 2019 ; Lanoix et al, 2012 ; Shimada et al, 2016 ) and gestational diabetes mellitus ( Laste et al, 2021 ; Shimada et al, 2016 ) compared with normal pregnancies. The exchange of melatonin between maternal and fetal circulation is unrestricted, and this circulation provides photoperiodic information to the fetus ( Tamura et al, 2008 ).…”

Section: Introductionmentioning

confidence: 89%

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A randomized controlled trial on the effect of blue-blocking glasses compared to partial blue-blockers on melatonin profile among nulliparous women in third trimester of the pregnancy

Liset

Grønli

Henriksen

et al. 2022

Neurobiology of Sleep and Circadian Rhythms

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Objective In pregnancy melatonin regulates circadian rhythms, induce sleep, and has a neuroprotective positive effect on fetal development. Artificial blue light in the evening delays and suppresses melatonin production. Thus, we investigated the effect of blocking blue light on the melatonin profile. Methods A randomized controlled trial (n=30 blue-blocking glasses vs. n=30 control glasses with partial blue-blocking effect) including healthy nulliparous pregnant women in the beginning of the third trimester. Salivary melatonin and subjective sleep were measured before and after two weeks of intervention/control condition. Saliva was sampled at 30-min intervals from 3 h before normal bedtime. Melatonin onset was set at 4.0 pg/ml. Results Due to missing data melatonin onset was estimated for 47 participants. At posttreatment, melatonin onset advanced by 28 min in the blue-blocking group compared with the control condition (p=.019). Melatonin levels were significantly higher, favoring the blue-blocking glass condition, at clock time 20:00, 21:00 and 22:00 h, and for sample number 3 and 4. The phase angle (time interval) between melatonin onset and sleep bedtime and sleep onset time increased within the blue blocking group (+45 min and +41 min, respectively), but did not reach statistical significance compared to control condition (+13 min and +26 min, respectively). Conclusion Blocking blue light in the evening had a positive effect on the circadian system with an earlier onset and rise of melatonin levels in healthy nulliparous pregnant women. This demonstrated the effectiveness and feasibility of a simple non-pharmacological chronobiological intervention during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

A randomized controlled trial on the effect of blue-blocking glasses compared to partial blue-blockers on melatonin profile among nulliparous women in third trimester of the pregnancy

Liset

Grønli

Henriksen

et al. 2022

Neurobiology of Sleep and Circadian Rhythms

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“…With a view toward melatonin's antioxidant properties, it is striking that blood levels and placental synthesis of melatonin decline significantly in women with severe preeclampsia (74)(75)(76). In a meta-analysis by Dou et al (77), these data were corroborated and melatonin levels were found to correlate with the severity of the disease. In terms of a possible beneficial effect of melatonin on placental tissues, Hannan et al (78) demonstrated that melatonin in vitro upregulated antioxidant response genes in human placental trophoblasts as well as in umbilical vein endothelial cells, albeit only at extremely high (1 mM) levels.…”

Section: Melatonin and Pregnancymentioning

confidence: 97%

Melatonin and Female Reproduction: An Expanding Universe

Olcese

2020

Front. Endocrinol.

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For more than a half century the hormone melatonin has been associated with vertebrate reproduction, particularly in the context of seasonal breeding. This association is due in large measure to the fact that melatonin secretion from the pineal gland into the peripheral circulation is a nocturnal event whose duration is reflective of night length, which of course becomes progressively longer during winter months and correspondingly shorter during the summer months. The nocturnal plasma melatonin signal is conserved in essentially all vertebrates and is accessed not just for reproductive rhythms, but for seasonal cycles of metabolic activities, immune functions, and behavioral expression. A vast literature on melatonin and vertebrate biology has accrued over the past 60 years since melatonin's discovery, including the broad topic of animal reproduction, which is far beyond the scope of this human-focused review. Although modern humans in the industrialized world appear in general to have little remaining reproductive seasonality, the relationships between melatonin and human reproduction continue to attract widespread scientific attention. The purpose of this chapter is to draw attention to some newer developments in the field, especially those with relevance to human fertility and reproductive medicine. As the vast majority of studies have focused on the female reproductive system, a discussion of the potential impact of melatonin on human male fertility will be left for others.

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“…Several reports suggest that melatonin plays a role as a protector agent during pregnancy for the mother, fetus, and placenta physiology ( Dou et al, 2019 ; Nagasawa et al, 2021 ; Sun et al, 2021 ). Melatonin could directly stabilize blood pressure in pathological pregnancies via modifying previously described genes or new targets, which requires more studies to be conducted during gestational hypertension, preeclampsia, and other pathologies.…”

Section: Hypertension and Pregnancymentioning

confidence: 99%

“…The impaired melatonin production is associated with complications during pregnancy, such as severe Preeclampsia, hypertension, and proteinuria. During severe Preeclampsia, Melatonin levels in women are reduced ( Dou et al, 2019 ). However, melatonin supplementation can reduce oxidative stress and hypertension during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Supraphysiological Role of Melatonin Over Vascular Dysfunction of Pregnancy, a New Therapeutic Agent?

et al. 2021

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Hypertension can be induced by the disruption of factors in blood pressure regulation. This includes several systems such as Neurohumoral, Renin-angiotensin-aldosterone, the Circadian clock, and melatonin production, which can induce elevation and non-dipping blood pressure. Melatonin has a supraphysiological role as a chronobiotic agent and modulates vascular system processes via pro/antiangiogenic factors, inflammation, the immune system, and oxidative stress regulation. An elevation of melatonin production is observed during pregnancy, modulating the placenta and fetus’s physiological functions. Their impairment production can induce temporal desynchronization of cell proliferation, differentiation, or invasion from trophoblast cells results in vascular insufficiencies, elevating the risk of poor fetal/placental development. Several genes are associated with vascular disease and hypertension during pregnancy via impaired inflammatory response, hypoxia, and oxidative stress, such as cytokines/chemokines IL-1β, IL-6, IL-8, and impairment expression in endothelial cells/VSMCs of HIF1α and eNOS genes. Pathological placentas showed differentially expressed genes (DEG), including vascular genes as CITED2, VEGF, PL-II, PIGF, sFLT-1, and sENG, oncogene JUNB, scaffolding protein CUL7, GPER1, and the pathways of SIRT/AMPK and MAPK/ERK. Additionally, we observed modification of subunits of NADPH oxidase and extracellular matrix elements, i.e., Glypican and Heparanase and KCa channel. Mothers with a low level of melatonin showed low production of proangiogenic factor VEGF, increasing the risk of preeclampsia, premature birth, and abortion. In contrast, melatonin supplementation can reduce systolic pressure, prevent oxidative stress, induce the activation of the antioxidants system, and lessen proteinuria and serum level of sFlt-1. Moreover, melatonin can repair the endothelial damage from preeclampsia at the placenta level, increasing PIGF, Nrf-2, HO-1 production and reducing critical markers of vascular injury during the pregnancy. Melatonin also restores the umbilical and uterine blood flow after oxidative stress and inhibits vascular inflammation and VCAM-1, Activin-A, and sEng production. The beneficial effects of melatonin over pathological pregnancies can be partially observed in normal pregnancies, suggesting the dual role of/over placental physiology could contribute to protection and have therapeutic applications in vascular pathologies of pregnancies in the future.

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The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis

Cited by 14 publications

References 28 publications

A randomized controlled trial on the effect of blue-blocking glasses compared to partial blue-blockers on melatonin profile among nulliparous women in third trimester of the pregnancy

A randomized controlled trial on the effect of blue-blocking glasses compared to partial blue-blockers on melatonin profile among nulliparous women in third trimester of the pregnancy

Melatonin and Female Reproduction: An Expanding Universe

Supraphysiological Role of Melatonin Over Vascular Dysfunction of Pregnancy, a New Therapeutic Agent?

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