Serological markers of autoimmunity ‎in women with polycystic ovary ‎syndrome

Abstract

In the present study, we evaluate the serum level of common autoimmunologic markers in ‎women with polycystic ovary syndrome (PCOS) and study their relationship with ‎hormonal ‎parameters. The study was ‎an observational case-control study, done in a Tertiary referral hospital, the study ‎included ‎50 women with polycystic ovary syndrome and 50 matched control.‎ Serum levels of Antinuclear Antibody (ANA) and anti-double-stranded DNA (dsDNA) were significantly higher in polycystic ovary ‎syndrome women compared to control. Also, luteinizing hormone (LH), follicle stimulating hormone (FSH), and LH/FSH ratio were ‎significantly higher in polycystic ovary syndrome women compared to control. ‎dsDNA had excellent ability to differentiate PCOS from control (AUC=0.901) while ANA had good discrimination ability ‎‎(AUC=0.809). There was a significant direct relationship between ANA, dsDNA, and TSH ‎with FSH in PCOS women, ‏also a ‎significant direct relationship between ANA and TSH with LH, while ‎DsDNA did not correlate with LH. In conclusion, there is a clear relationship between immunological markers (ANA, dsDNA) with ‎‎polycystic ovary syndrome in various components of the disease, dsDNA offer better ability than ANA as a predictor of PCOS, indicating that dsDNA can be used as a non-invasive diagnostic tool for PCOS.

Dapagliflozin mitigates oxidative stress, inflammatory, and histopathological markers of aging in mice

“…This leads to increased glucose filtration via the renal system and subsequent excretion in the urine, ultimately decreasing glucose levels. Notably, this effect is independent of the action of insulin [ 13 - 15 ]. DAPA has also been recognized for its antioxidant properties, offering cellular protection by scavenging oxidative free radicals.…”

Role of hematological indices in predicting preeclampsia and its severity: retrospective case–control study

“…To this end, several biological factors have been examined, such as D-dimer, soluble fms-like tyrosine kinase-1, and PDW. [18,[21][22][23] Some authors found a link between changes in hematological parameters like NLR coupled with some biochemical parameters like uric acid, and both were good predictors of maternal and neonatal outcomes. [24] Current guidelines define PE based on hypertension and supporting findings like thrombocytopenia, increase in renal and liver indices, and other markers that indicate end-organ damage, and these supporting findings are necessary to confirm the diagnosis of PE and ascertain its severity.…”

“…To this end, several biological factors have been examined, such as D-dimer, soluble fms-like tyrosine kinase-1, and PDW. [ 18 , 21 – 23 ] Some authors found a link between changes in hematological parameters like NLR coupled with some biochemical parameters like uric acid, and both were good predictors of maternal and neonatal outcomes. [ 24 ]…”