Severe coronavirus disease 2019 (COVID-19) infection leads to multifactorial acute respiratory distress syndrome (ARDS), with little therapeutic success. The pathophysiology associated with ARDS or post-ARDS is not yet well understood. We hypothesize that amyloid formation occurring due to protein homeostasis disruption can be one of the complications associated with COVID-19-induced-ARDS.
AbstractWe have developed Fullerene-C60 nanoformulations containing discrete sized nanoparticles by dispersing concentration range of Fullerene. Small sized particles are cytotoxic while larger ones are cell proliferative. The cell proliferative property is used for tissue repair in cellular and animal wound models.
Nanoparticle-based drug delivery systems for crossing blood-brain-barrier employ diverse strategies. Coating of the nanoparticles with non-ionic surfactants is often employed for enhancing the delivery process. Polysorbate 80 is one of...
<p>Nanomedicine is envisioned to have a tremendous impact on targeted drug
delivery in future. Coating of nanoparticles with non-ionic surfactants has
been often employed for enhancing targeting in drug delivery systems. Polysorbate
80 is one of the non-ionic surfactants
used often as a coating agent for receptor-mediated endocytosis into the brain.
However, very few studies have been done to investigate the actual amount of
the surfactant adsorbed or the mechanism of adsorption onto the nanoparticles. We
had developed an assay using an ATR-FTIR method for quantiation and adsorption
mechanism of polysorbate 80 on PLGA nanoparticles. Here we show the analytical
validation of this method, for exploring its suitability for its intended purpose in industries. To
comply with regulatory bodies and for standardization, we have followed the ICH
and FDA guidelines for analytical validation and investigated the required
criteria i.e. accuracy, precision, linearity, range ,limit of detection and
quantitation. The method successfully complied with all regulatory criteria and
is therefore suitable for successful use in industry, academia and by regulatory
bodies.</p>
Acute respiratory distress syndrome (ARDS) involves death of lung epithelial cells. ARDS is a leading reason behind mortality in respiratory infections. Here we show a proof-of-concept that a Fullerene nanoformulation can be used for the regeneration of cells treated with apoptosis-inducing molecules, suggeting its potential for ARDS therapy.
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