A total of 320 species from 42 families were registered in the herpetobios (stratobiont and epigeobiont beetles) of the urbocenosis of Kharkiv. Among these more than 160 species are recorded for the first time for this metropolis. Four species of ground beetles (Notiophilus germinyi Fauvel, Clivina fossor L., Laemostenus terricola Herbst and Masoreus wetterhali Gyll.) were not listed for Ukraine in the Catalogue of Palearctic Coleoptera. The species Omosita japonica Reitter, 1874 (Nitidulidae) is new for Ukranian fauna. Moreover, 93 species from 17 families are the dominant species (at least in one of the urban ecosystems). Among these, eudominants are represented with almost 20 species, but the number of eudomonants did not exceed ten species in separate urban cenoses. Carabidae (80), Staphylinidae (36), Curculionidae (32) and Tenebrionidae (8 species) dominate both, in species composition and abundance. The total part of these groups reached at least 90% of Coleoptera, recorded in urban-cenosis. Separate species of Silphidae, Dermestidae, Elateridae, Chrysomelidae, Leiodidae, Coccinellidae, Nitidulidae, Scarabaeidae, Histeridae and Lucanidae were sporadically usual in most plots. They accounted almost 9% of the total quantity of all beetles in transformed cenoses. Among these, a greater number of species are found within the families of Scarabaeidae (33), Chrysomelidae (16), Elateridae (14), Histeridae (12), Coccinellidae (11) and Nitidulidae (11), Silphidae (6) and Dermestidae (6). The rest of the families are represented with 1–4 species. All beetles registered in herpetobios belong to three groups. Typical inhabitants of herpetobios prevailed (about 200 species from 22 families, at least 90% of all Coleoptera). The proportion of species sporadically associated with herpetobios (more than 40 species from 10 families) was about 5% of all beetles. Random components of herpetobios are represented by more than 70 species from 10 families, and their total share did not exceed 3% of all Coleoptera. A preliminary taxonomic review of coleopterofauna was carried out in different urbocenoses. The number of species in urbocenosises ranged from 101 (Forest Park) to 124 (urban parks). In other green plantings of the city, the species diversity reached 105–118 species. The number of dominant beetles in different areas ranged from 37 to 60 species.
В обзоре предс тавлены данные литературы о формировании иммунного ответа при туберкулезе, об особенностях клеточного и гуморального звена в зависимости от выделения лекарственно-чувствительных и лекарственно-устойчивых штаммов M. tuberculosis. Показана роль цитокинов, генетических факторов при нарушениях иммунных реакций, влияющих на патоморфоз и клинические проявления туберкулеза.
Introduction. Nontuberculous mycobacteria (NTM) are widespread in the environment and can cause various diseases in humans, especially immunocompromised patients. Hypothesis. Treatment of diseases caused by NTM is a complicated issue, mainly due to the resistance of the pathogen to most antimicrobial agents. Bedaquiline (Bdq) is now widely used for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Aim. The main goal of our study was to evaluate the activity of Bdq against Mycobacterium avium complex (MAC), the most common species among NTM. Methodology. A total of 166 MAC cultures (124 Mycobacterium avium and 42 Mycobacterium intracellulare ) were studied. The minimum inhibitory concentrations (MICs) of Bdq for M. avium and M. intracellulare were obtained by twofold serial dilutions in the Middlebrook 7H9 medium. MIC ranges were determined and the MIC50, MIC90 and ECOFF values were obtained. Results. The MICs in respect of M. avium ranged from 0.003 to 1.0 µg ml−1; those for M. intracellulare ranged from 0.003 to 0.5 µg ml−1. The Bdq MIC50 and MIC90 values were found to be 0.015 and 0.12 µg ml−1 , respectively, for M. avium and 0.007 and 0.06 µg ml−1, respectively, for M. intracellulare . The tentative ECOFF values for M. avium and M. intracellulare were 0.12 and 0.06 µg ml−1, respectively. Conclusion. The main bedaquiline susceptibility parameters for MAC strains isolated in the Moscow region were determined.
Introduction. Extensive drug resistance (XDR) M. Tuberculosis (MBT) is considered the main factor that reduces the effectiveness of the treatment of TB patients around the world, including Russia. A significant role in improving the effectiveness of chemotherapy (CT) in people with resistant TB belongs to the introduction of new anti-TB drugs, the first of which was bedaquiline (LP-002281).Objective. To assess the profile of an XDR-TB patient receiving bedaquiline and the efficacy of chemotherapy regimens including bedaquiline in patients with XDR pulmonary tuberculosis.Materials and methods. The study is retrospective, non-comparative, descriptive. The data of 88 patients who received bedaquiline in the XDR-TB treatment regimen in anti-tuberculosis institutions of the Saratov region in 2017–2018.Results. Patients with chronic TB prevailed – 50/88 [56.8%, 95% CI 46.3–67.4], every fourth patient had a history of surgery. The cessation of bacterial excretion, confirmed by bacterioscopy, was achieved in 51/67 [76.1%, 95% CI 65.7–86.5] patients; by cultural method – in 47/67 [70,1%, 95% CI 59.0–81.3]. Negative sputum smear in a significant proportion of patients 43/51 [84.3%, 95% CI 52.4–75.9] was observed after 12 weeks of therapy, negative cultures in 36/47 [76.6%, 95% CI 41.6–65.9] – after 16 weeks.Discussion. Compared to individual patient analyzes – 43% success rate in the treatment of XDR-TB, in our cohort of XDR-TB patients treated with bedaquiline, the success rate was 53.4%, which is consistent with data from a large study describing the safety in 2017, tolerability and efficacy of bedaquiline and could be higher in the absence of “discontinuations from treatment”.Conclusion. The regimens of treatment of patients with XDR-tuberculosis with the inclusion of bedaquiline are effective in terms of the termination of bacterial excretion, confirmed by bacterioscopy and culture in patients with a complex course of a specific process with previous ineffective therapy.
The review presents methods for management of free radical reactions in pulmonary tuberculosis patients which are of great importance for relief of clinical symptoms, pathomorphological changes, and the outcome of the disease. It describes the effect of various antioxidant drugs on the course of tissue inflammatory reaction and the development of destructive changes in the lungs.
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