Specific Features of the Immune Response to Tuberculosis When Drug Susceptible and Drug Resistant Strains of M. Tuberculosis Are Detected

Shovkun, Ludmila; Kudlay, Dmitry; Nikolenko, N. Yu.; Кампос, Е. Д.; Харсеева, Г Г

doi:10.21292/2075-1230-2019-97-6-44-49

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…The main manifestations are multiple nodules, patchy shadows, pulmonary consolidation, hilar and mediastinal lymph node enlargement. The incidence of cavities in older children (5–14 years old) with DR-TB is higher than that in children less than 5 years old with DR-TB, but is similar to that of DS-TB in children of the same age ( 68 ). Tree-in-bud sign is common and calcification is rare.…”

Section: Imaging Diagnosismentioning

confidence: 70%

“…Compared with DS-PTB in children of the same age group, DR children in this age group have more extensive distribution of pulmonary lesions, and bilateral lungs are often involved ( Figure 4 ). The most common imaging manifestations are multiple nodules (including miliary nodules), followed by pulmonary consolidation, with a low incidence of cavitation ( 68 , 69 ). Tree-in-bud sign and calcification are rare.…”

Section: Imaging Diagnosismentioning

confidence: 99%

“…Hilar and mediastinal lymph node enlargement is common, but CT signs of bronchial TB such as bronchial stenosis, thickened tube wall, and unsmooth inner wall are rare ( 68 ), and the incidence rate is lower than the incidence rate of bronchial tuberculosis in children with DS-PTB ( 70 , 71 ). The incidence of pleural effusion, pleural thickening is low ( 68 , 69 ), and it is often accompanied by severe extrapulmonary TB, of which intracranial TB is the most common. The incidence of extrapulmonary TB such as intracranial TB in DR children is higher than that in children with DS-PTB ( 72 , 73 ).…”

Section: Imaging Diagnosismentioning

confidence: 99%

“…The incidence of bronchial TB is higher in DR-TB than in DS-TB ( 70 ). Pleural thickening is common, but the incidence of pleural effusion is low ( 68 ), which is much lower than the incidence of tuberculous pleural effusion in children with DS-PTB ( 73 , 74 ).…”

Section: Imaging Diagnosismentioning

confidence: 99%

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Chinese expert consensus on imaging diagnosis of drug-resistant pulmonary tuberculosis

Xu,

Lu,

et al. 2024

Quant Imaging Med Surg

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Tuberculosis (TB) remains one of the major infectious diseases in the world with a high incidence rate. Drug-resistant tuberculosis (DR-TB) is a key and difficult challenge in the prevention and treatment of TB. Early, rapid, and accurate diagnosis of DR-TB is essential for selecting appropriate and personalized treatment and is an important means of reducing disease transmission and mortality. In recent years, imaging diagnosis of DR-TB has developed rapidly, but there is a lack of consistent understanding. To this end, the Infectious Disease Imaging Group, Infectious Disease Branch, Chinese Research Hospital Association; Infectious Diseases Group of Chinese Medical Association of Radiology; Digital Health Committee of China Association for the Promotion of Science and Technology Industrialization, and other organizations, formed a group of TB experts across China. The conglomerate then considered the Chinese and international diagnosis and treatment status of DR-TB, China’s clinical practice, and evidence-based medicine on the methodological requirements of guidelines and standards. After repeated discussion, the expert consensus of imaging diagnosis of DR-PB was proposed. This consensus includes clinical diagnosis and classification of DR-TB, selection of etiology and imaging examination [mainly X-ray and computed tomography (CT)], imaging manifestations, diagnosis, and differential diagnosis. This expert consensus is expected to improve the understanding of the imaging changes of DR-TB, as a starting point for timely detection of suspected DR-TB patients, and can effectively improve the efficiency of clinical diagnosis and achieve the purpose of early diagnosis and treatment of DR-TB.

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Section: Imaging Diagnosismentioning

confidence: 70%

Section: Imaging Diagnosismentioning

confidence: 99%

Section: Imaging Diagnosismentioning

confidence: 99%

Section: Imaging Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Chinese expert consensus on imaging diagnosis of drug-resistant pulmonary tuberculosis

Xu,

Lu,

et al. 2024

Quant Imaging Med Surg

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Antituberculosis Drug Allergy in Patients With Multidrug-Resistant Tuberculosis

Maykanaev¹,

Toktogonova²,

Dudenko³

et al. 2021

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Specific Features of Pulmonary Tuberculosis Patients Treatment with Interferon-Gamma Depending on the Nature of the Tissue Inflammatory Reaction

Shlyk,

Kudlay,

Kampos

et al. 2023

Tuberk. bolezni lëgk.

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The objective: to evaluate effectiveness of treatment of infiltrative pulmonary tuberculosis patients with exudative or productive types of the tissue inflammatory reaction when additional immunotherapy with recombinant IFN-γ is used.Subjects and Methods. 127 infiltrative tuberculosis patients were enrolled in the study, of them 66 had an exudative type of the inflammatory reaction (2 Groups OG-1 and GS-1 were formed), 61 had a proliferative type (2 Groups OG-2 and GS-2 were formed). Patients from OG-1 and OG-2 Groups additionally received different regimens with recombinant interferon-γ.Result: Comprehensive treatment of infiltrative tuberculosis including intramuscular administration (according to a certain regimen) of recombinant IFN-γ contributes to achievement of pronounced positive changes of clinical and radiological symptoms in patients with both exudative and productive types of the tissue inflammatory reaction. In the groups treated with recombinant IFN-γ, restoration of the cellular immune response, cellular cooperation, normalization of the cytokine profile and increased phagocytosis activity were confirmed by the results of laboratory tests.

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Specific Features of the Immune Response to Tuberculosis When Drug Susceptible and Drug Resistant Strains of M. Tuberculosis Are Detected

Cited by 3 publications

References 21 publications

Chinese expert consensus on imaging diagnosis of drug-resistant pulmonary tuberculosis

Chinese expert consensus on imaging diagnosis of drug-resistant pulmonary tuberculosis

Antituberculosis Drug Allergy in Patients With Multidrug-Resistant Tuberculosis

Specific Features of Pulmonary Tuberculosis Patients Treatment with Interferon-Gamma Depending on the Nature of the Tissue Inflammatory Reaction

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